Defresne M P, Rongy A M, Greimers R, Boniver J
Leuk Res. 1986;10(7):783-9. doi: 10.1016/0145-2126(86)90298-5.
After a leukemogenic split dose course of irradiation, thymic nurse cells (TNCs) disappear. We have correlated this with the loss of an epithelial cell surface antigen (recognized by monoclonal antibody ER-TR3 and tentatively identified as Ia). In addition, epithelial cells have lost their capacity to interact with fetal thymocytes in vitro. Marrow grafting early after irradiation, that prevents the development of lymphomas, restores thymic nurse cells and thymocyte population. Such reconstitution and lymphoma prevention were not observed when marrow grafting was performed later (1 month after irradiation) during the preleukemic period.
在白血病致分裂剂量的照射疗程后，胸腺哺育细胞（TNCs）消失。我们已将此与一种上皮细胞表面抗原（被单克隆抗体ER - TR3识别并初步鉴定为Ia）的丧失联系起来。此外，上皮细胞在体外已失去与胎儿胸腺细胞相互作用的能力。照射后早期进行骨髓移植可预防淋巴瘤的发生，并能恢复胸腺哺育细胞和胸腺细胞群体。而在白血病前期（照射后1个月）进行骨髓移植时，则未观察到这种重建和淋巴瘤预防现象。
