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分次X线照射诱导的小鼠胸腺瘤具有特定的T细胞受体重排以及与第15至16天胎儿胸腺细胞相关的特征。

Murine thymomas induced by fractionated-X-irradiation have specific T-cell receptor rearrangements and characteristics associated with day-15 to -16 fetal thymocytes.

作者信息

Amari N M, Meruelo D

机构信息

Department of Pathology, New York University Medical Center, New York 10016.

出版信息

Mol Cell Biol. 1987 Dec;7(12):4159-68. doi: 10.1128/mcb.7.12.4159-4168.1987.

DOI:10.1128/mcb.7.12.4159-4168.1987
PMID:2830482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368096/
Abstract

We report here that specific T-cell receptor rearrangements were observed in fractionated-X-irradiation-induced murine leukemias. Consistent gamma-chain rearrangements, limited beta-chain rearrangements, and no detectable alpha-chain rearrangements were observed. Gene expression studies revealed that, in comparison with normal thymus tissue, expression of alpha T-cell receptor genes was lower in the thymomas, beta expression was much higher but approximately equal to that of normal thymocytes, and gamma expression was significantly increased. After coupling these data with those from analyses using reagents against other surface markers, such as Lyt-2, L3T4, H-2, IL-2R and MEL-14, we concluded that the target T cells for fractionated-X-irradiation-induced transformation resemble fetal thymocytes from days 15 and 16 of gestation.

摘要

我们在此报告，在分次X线照射诱导的小鼠白血病中观察到了特定的T细胞受体重排。观察到一致的γ链重排、有限的β链重排，且未检测到α链重排。基因表达研究显示，与正常胸腺组织相比，胸腺瘤中α T细胞受体基因的表达较低，β表达高得多但与正常胸腺细胞的表达大致相当，γ表达显著增加。将这些数据与使用针对其他表面标志物（如Lyt-2、L3T4、H-2、IL-2R和MEL-14）的试剂进行分析得到的数据相结合后，我们得出结论，分次X线照射诱导转化的靶T细胞类似于妊娠第15和16天的胎儿胸腺细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/e6d9ef26d253/molcellb00084-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/5fe123c08f4f/molcellb00084-0021-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/b90bdc42ca65/molcellb00084-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/794caee94942/molcellb00084-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/79c2b264b6f9/molcellb00084-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/f0cdc44b00dd/molcellb00084-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/3499fff2f800/molcellb00084-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/e6d9ef26d253/molcellb00084-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/5fe123c08f4f/molcellb00084-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/f629cf584b14/molcellb00084-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/b90bdc42ca65/molcellb00084-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/794caee94942/molcellb00084-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/79c2b264b6f9/molcellb00084-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/f0cdc44b00dd/molcellb00084-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/3499fff2f800/molcellb00084-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14dc/368096/e6d9ef26d253/molcellb00084-0026-a.jpg

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Murine thymomas induced by fractionated-X-irradiation have specific T-cell receptor rearrangements and characteristics associated with day-15 to -16 fetal thymocytes.分次X线照射诱导的小鼠胸腺瘤具有特定的T细胞受体重排以及与第15至16天胎儿胸腺细胞相关的特征。
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