Mohammedsaeed Walaa, Ahmedseedi Ibrahim, Alahmadey Ziab
Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, Madinah, SAU.
Department of Internal Medicine, Ohud Hospital Madinah, Madinah, SAU.
Cureus. 2023 May 23;15(5):e39409. doi: 10.7759/cureus.39409. eCollection 2023 May.
Purpose Most of the research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) has mainly focused on the lungs as a key organ involved in the disease, while very little data is available regarding the involvement of other organs including the liver and kidneys, which are also reported to be severely affected by the disease. The objective of this study was to analyze the effect of COVID-19 disease on liver and kidney functions and to determine their association with the severity and mortality of the disease. This was a retrospective cross-sectional analysis of medical records. Methods A total of 100 confirmed COVID-19 adult patients from Madinah, Saudi Arabia hospitalized between April 28 and June 30, 2020, were included and categorized into asymptomatic, mild to moderate, and severely ill patients. We analyzed the clinical status of liver and renal functioning in all three groups. Results Most patients (51%) were diagnosed with mild to moderate disease, 27% of patients were severely ill and 22% of patients were asymptomatic. The liver and renal functional analysis showed that the severity of the COVID-19 patients was significantly associated with renal impairments exhibiting higher levels of creatinine and urea (P<0.05) with high levels of liver enzymes as indicators for liver damage. Conclusion We concluded from the present study that severely ill COVID-19 patients were more prone to have abnormal liver and renal functions. The present findings, however, demand further study of the association between liver and kidney impairments with COVID-19 infection for better clinical management.
目的 大多数关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）（冠状病毒病2019 [COVID-19]）的研究主要集中在肺部这一参与该疾病的关键器官，而关于包括肝脏和肾脏在内的其他器官受累情况的数据却非常少，据报道这些器官也受到该疾病的严重影响。本研究的目的是分析COVID-19疾病对肝脏和肾脏功能的影响，并确定它们与疾病严重程度和死亡率的关联。这是一项对病历的回顾性横断面分析。方法 纳入了2020年4月28日至6月30日期间在沙特阿拉伯麦地那住院的100例确诊COVID-19成年患者，并将其分为无症状、轻至中度和重症患者。我们分析了所有三组患者的肝脏和肾脏功能的临床状况。结果 大多数患者（51%）被诊断为轻至中度疾病，27%的患者为重症，22%的患者无症状。肝脏和肾脏功能分析表明，COVID-19患者的严重程度与肾功能损害显著相关，肌酐和尿素水平较高（P<0.05），肝酶水平升高作为肝损伤指标。结论 我们从本研究得出结论，重症COVID-19患者更容易出现肝脏和肾脏功能异常。然而，目前的研究结果需要进一步研究肝脏和肾脏损害与COVID-19感染之间的关联，以便更好地进行临床管理。
