Miteu Goshen D, Achinebiri Praise, Raghunathan Narasimhan, Sankaran Sathyanarayanan
School of Biosciences, Biotechnology, University of Nottingham, England, UK.
Department of Biochemistry, Caleb University, Imota, Lagos, Nigeria.
Ann Med Surg (Lond). 2023 May 3;85(6):3226-3231. doi: 10.1097/MS9.0000000000000760. eCollection 2023 Jun.
Antimicrobial resistance (AMR) is still a formidable global public health challenge, as microorganisms, including bacteria, viruses, fungi, and parasites, evolve resistance to commonly used drugs, particularly antibiotics. The preservation of last-resort antimicrobials is critical for treating multi-drug-resistant infections; however, their indiscriminate use can exacerbate AMR crisis. This short communication delves into the multifaceted challenges, innovative strategies, and promising future directions to combat AMR effectively. Factors such as inappropriate prescription practices and the dearth of novel antibiotics contribute to the emergence of AMR. By implementing antimicrobial stewardship programs and fostering public education, we can mitigate the misuse of these vital drugs. Future research endeavors should concentrate on the development of cutting-edge drugs and diagnostic technologies to address AMR with enhanced precision and efficiency. Additionally, robust surveillance systems are crucial for monitoring antibiotic use and resistance patterns, providing valuable insights to inform policy decisions. A concerted, collaborative effort from governments, policymakers, healthcare providers, researchers, and other stakeholders is indispensable for overcoming the global health crisis posed by AMR.
抗菌药物耐药性（AMR）仍然是一个严峻的全球公共卫生挑战，因为包括细菌、病毒、真菌和寄生虫在内的微生物对常用药物，尤其是抗生素产生了耐药性。保留最后手段的抗菌药物对于治疗多重耐药感染至关重要；然而，它们的滥用会加剧AMR危机。本简短通讯深入探讨了有效应对AMR的多方面挑战、创新策略和有前景的未来方向。不适当的处方行为和新型抗生素的匮乏等因素导致了AMR的出现。通过实施抗菌药物管理计划和加强公众教育，我们可以减少这些重要药物的滥用。未来的研究应专注于开发前沿药物和诊断技术，以更精确、高效地应对AMR。此外，强大的监测系统对于监测抗生素使用和耐药模式至关重要，可为政策决策提供有价值的见解。政府、政策制定者、医疗保健提供者、研究人员和其他利益相关者齐心协力、开展合作，对于克服AMR带来的全球卫生危机必不可少。
