Department of Electronic Engineering, Lunghwa University of Science and Technology, Guishan, Taoyuan County, Taiwan.
J Biomater Sci Polym Ed. 2023 Oct;34(15):2124-2143. doi: 10.1080/09205063.2023.2230842. Epub 2023 Jul 7.
Collagen plays an important role in hemostasis and tissue repair processes. Traditional passive wound dressings like gauze, bandage, and cotton wool could hardly fit the open wounds and exerted no active effect on wound healing. Even worse, they would adhere to the skin tissue, causing dehydration and second injury upon replacement. Polyester is commonly used in the medical field and is a safe and inexpensive polymer. Due to the hydrophobic surface, polyester does not adhere to tissue; however, polyester does not have the hemostatic properties. We designed a material composed of collagen and polyester, encapsulated hydrolyzed collagen in polyester particles, and made collagen-polyester non-woven fabric by melt blowing method, The collagen content was 1% and the collagen-polyester dressing exhibited a hydrophobic nature, preventing moisture from sticking to its surface. The purpose of this study was to compare the hemostatic effect of collagen-polyester nonwovens with conventional polyester pads, and to observe the adhesion of the pads to the wound. The wound healing and shrinkage rates of collagen-polyester dressings and conventional pads were compared in a rat wound healing test. The hemostatic test showed that the polyester pads containing 1% collagen significantly shortened the bleeding time compared with the traditional polyester pads, and retained the hydrophobicity and non-adhesion properties. The collagen-polyester dressing had better angiogenesis and granulation degree than the control group on the 14th day, and reduced the wound shrinkage rate. Collagen polyester dressings have excellent hemostasis, regeneration, shrinkage reduction and non-adhering for wounds. Overall, the novel collagen-containing polyester dressing is ideal choice for wound dressings.
胶原蛋白在止血和组织修复过程中起着重要作用。传统的被动伤口敷料，如纱布、绷带和棉花，很难贴合开放性伤口，对伤口愈合也没有积极作用。更糟糕的是，它们会粘在皮肤组织上，在更换时会导致脱水和二次损伤。聚酯在医学领域中被广泛应用，它是一种安全且廉价的聚合物。由于其疏水表面，聚酯不会粘在组织上；然而，聚酯本身并没有止血性能。我们设计了一种由胶原蛋白和聚酯组成的材料，将水解胶原蛋白封装在聚酯颗粒中，并通过熔喷法制成胶原蛋白-聚酯无纺纤维。其中胶原蛋白的含量为 1%，这种胶原蛋白-聚酯敷料呈现出疏水性质，可以防止水分粘在其表面。本研究旨在比较胶原蛋白-聚酯非织造布与传统聚酯垫的止血效果，并观察垫对伤口的黏附情况。在大鼠伤口愈合试验中比较了胶原蛋白-聚酯敷料和传统聚酯垫的伤口愈合和收缩率。止血试验表明，与传统聚酯垫相比，含有 1%胶原蛋白的聚酯垫显著缩短了出血时间，同时保留了疏水性和非黏附性。在第 14 天，胶原蛋白-聚酯敷料的血管生成和肉芽形成程度优于对照组，并且减少了伤口收缩率。胶原蛋白聚酯敷料在止血、再生、减少收缩和不黏附伤口方面表现出色。总的来说，这种新型的含胶原蛋白聚酯敷料是一种理想的伤口敷料选择。
