Stan Diana, Codrici Elena, Enciu Ana-Maria, Olewnik-Kruszkowska Ewa, Gavril Georgiana, Ruta Lavinia Liliana, Moldovan Carmen, Brincoveanu Oana, Bocancia-Mateescu Lorena-Andreea, Mirica Andreea-Cristina, Stan Dana, Tanase Cristiana
DDS Diagnostic, 031427 Bucharest, Romania.
Doctoral School of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania.
Gels. 2023 Jun 9;9(6):476. doi: 10.3390/gels9060476.
Healthcare professionals face an ongoing challenge in managing both acute and chronic wounds, given the potential impact on patients' quality of life and the limited availability of expensive treatment options. Hydrogel wound dressings offer a promising solution for effective wound care due to their affordability, ease of use, and ability to incorporate bioactive substances that enhance the wound healing process. Our study aimed to develop and evaluate hybrid hydrogel membranes enriched with bioactive components such as collagen and hyaluronic acid. We utilized both natural and synthetic polymers and employed a scalable, non-toxic, and environmentally friendly production process. We conducted extensive testing, including an in vitro assessment of moisture content, moisture uptake, swelling rate, gel fraction, biodegradation, water vapor transmission rate, protein denaturation, and protein adsorption. We evaluated the biocompatibility of the hydrogel membranes through cellular assays and performed instrumental tests using scanning electron microscopy and rheological analysis. Our findings demonstrate that the biohybrid hydrogel membranes exhibit cumulative properties with a favorable swelling ratio, optimal permeation properties, and good biocompatibility, all achieved with minimal concentrations of bioactive agents.
鉴于对患者生活质量的潜在影响以及昂贵治疗选择的有限可用性，医疗保健专业人员在处理急性和慢性伤口方面面临着持续的挑战。水凝胶伤口敷料因其价格实惠、使用方便以及能够加入促进伤口愈合过程的生物活性物质，为有效的伤口护理提供了一个有前景的解决方案。我们的研究旨在开发和评估富含胶原蛋白和透明质酸等生物活性成分的混合水凝胶膜。我们使用了天然和合成聚合物，并采用了可扩展、无毒且环保的生产工艺。我们进行了广泛的测试，包括对水分含量、水分吸收、溶胀率、凝胶分数、生物降解、水蒸气透过率、蛋白质变性和蛋白质吸附的体外评估。我们通过细胞试验评估了水凝胶膜的生物相容性，并使用扫描电子显微镜和流变学分析进行了仪器测试。我们的研究结果表明，生物混合水凝胶膜具有累积特性，具有良好的溶胀率、最佳的渗透性能和良好的生物相容性，所有这些都是在生物活性剂浓度最低的情况下实现的。
