Xie Feng, Zou Liangyu, Xu Zikai, Ou Xiaolan, Guo Wenlai, Gao Yang, Gao Guanghui
Polymeric and Soft Materials Laboratory, School of Chemical Engineering and Advanced Institute of Materials Science, Changchun University of Technology, No. 2055, Yan'an Street, Changchun 130000, PR China; Beijing Graphene Institute, Beijing 100095, PR China.
Department of Hand Surgery, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, PR China.
Int J Biol Macromol. 2022 Dec 31;223(Pt A):391-403. doi: 10.1016/j.ijbiomac.2022.11.013. Epub 2022 Nov 7.
Recently, hydrogel dressings have been rapidly developed for wound healing. However, it is still a huge challenge to endow hydrogel wound dressings with excellent hemostatic performance. Here, a new wound treatment material, foam gel wound dressing, is reported, which possesses rapid hemostasis and antibacterial properties. The foam gel dressing is composed of chitooligosaccharide modified graphene oxide (CG) nanocomposites and calcium alginate foam substrate. In this system, CG has a strong interaction with platelets, which is helpful for rapid hemostasis. So the wound dressing could stop bleeding quickly within 10 s. Meanwhile, CG also provides excellent antibacterial properties to dressings, which is conducive to wound healing. Full-thickness wound healing experiments showed that compared with blank control and CG-free foam gel dressings, CG-loaded foam gel dressings shows better healing properties, and the wounds covered with them are almost completely healed within 12 days. In addition, histological morphology analysis displays CG-loaded wound dressing could significantly accelerate wound healing by reducing the inflammatory response and promoting vascular remodeling. This unique strategy provides a simple and practical method for the clinical application of the next generation of wound dressings.
近年来，水凝胶敷料在伤口愈合方面得到了迅速发展。然而，赋予水凝胶伤口敷料优异的止血性能仍然是一个巨大的挑战。在此，报道了一种新型伤口治疗材料——泡沫凝胶伤口敷料，它具有快速止血和抗菌性能。泡沫凝胶敷料由壳寡糖修饰的氧化石墨烯（CG）纳米复合材料和海藻酸钙泡沫基质组成。在该体系中，CG与血小板有很强的相互作用，有助于快速止血。因此，伤口敷料能在10秒内迅速止血。同时，CG还为敷料提供了优异的抗菌性能，有利于伤口愈合。全层伤口愈合实验表明，与空白对照和不含CG的泡沫凝胶敷料相比，负载CG的泡沫凝胶敷料具有更好的愈合性能，覆盖有它们的伤口在12天内几乎完全愈合。此外，组织形态学分析显示，负载CG的伤口敷料可通过减轻炎症反应和促进血管重塑显著加速伤口愈合。这种独特的策略为下一代伤口敷料的临床应用提供了一种简单实用的方法。
