Sellitto Maria Rosaria, Amante Chiara, Aquino Rita Patrizia, Russo Paola, Rodríguez-Dorado Rosalía, Neagu Monica, García-González Carlos A, Adami Renata, Del Gaudio Pasquale
Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.
Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.
Gels. 2023 Jun 16;9(6):492. doi: 10.3390/gels9060492.
The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization of drug-loaded aerogel capsules through prilling in tandem with supercritical extraction. In particular, drug-loaded particles were produced by a recently developed inverse gelation method through prilling in a coaxial configuration. Particles were loaded with ketoprofen lysinate, which was used as a model drug. The core-shell particles manufactured by prilling were subjected to a supercritical drying process with CO that led to capsules formed by a wide hollow cavity and a tunable thin aerogel layer (40 μm) made of alginate, which presented good textural properties in terms of porosity (89.9% and 95.3%) and a surface area up to 417.0 m/g. Such properties allowed the hollow aerogel particles to absorb a high amount of wound fluid moving very quickly (less than 30 s) into a conformable hydrogel in the wound cavity, prolonging drug release (till 72 h) due to the in situ formed hydrogel that acted as a barrier to drug diffusion.
用于不同应用的气凝胶的生产已广为人知，但基于多糖的气凝胶在药物应用中的使用，特别是作为伤口愈合的药物载体，目前正在探索中。这项工作的主要重点是通过与超临界萃取串联造粒来生产和表征载药气凝胶胶囊。具体而言，载药颗粒是通过最近开发的反向凝胶化方法在同轴配置下造粒生产的。颗粒中装载了赖氨匹林，用作模型药物。通过造粒制造的核壳颗粒经过用CO2进行的超临界干燥过程，形成了由宽的中空腔和由藻酸盐制成的可调薄气凝胶层（40μm）组成的胶囊，该胶囊在孔隙率（89.9%和95.3%）和高达417.0m²/g的表面积方面具有良好的质地特性。这些特性使中空气凝胶颗粒能够大量吸收伤口液，并在不到30秒的时间内迅速进入伤口腔中顺应性水凝胶，由于原位形成的水凝胶作为药物扩散的屏障，从而延长了药物释放（直至72小时）。
