Department of Organic and Nano System Engineering, Konkuk University, Seoul 05029, Republic of Korea.
Division of Chemical Engineering, Konkuk University, Seoul 05029, Republic of Korea.
Int J Biol Macromol. 2020 Dec 1;164:2177-2185. doi: 10.1016/j.ijbiomac.2020.08.008. Epub 2020 Aug 4.
Herein, the dual-crosslinked chitosan aerogel was prepared using 1-butyl-3-methylimidazolium chloride, an ionic liquid, as a solvent. The hydroxyl groups were covalently crosslinked by epichlorohydrin (ECH), while the amino groups were ionically crosslinked by itaconic acid (IA). The chemical and ionic crosslinkings of the aerogels were analyzed using FT-IR and NMR. Both the types and the degree of crosslinking gave significant influences on the structures of the aerogels. The dual crosslinked aerogel with proper chemical crosslinking dose had the excellent swelling behavior. The prepared aerogel shows potential as a wound healing matrix, with low toxicity and antibacterial function.
在此，使用 1-丁基-3-甲基咪唑氯盐（一种离子液体）作为溶剂，制备了双交联壳聚糖气凝胶。羟基通过表氯醇（ECH）进行共价交联，而氨基通过衣康酸（IA）进行离子交联。使用傅里叶变换红外光谱（FT-IR）和核磁共振（NMR）分析了气凝胶的化学交联和离子交联。交联的类型和程度对气凝胶的结构有显著影响。具有适当化学交联剂量的双交联气凝胶具有优异的溶胀性能。所制备的气凝胶具有作为伤口愈合基质的潜力，具有低毒性和抗菌功能。
