Institute of Nanotechnology, Jordan University of Science and Technology, Irbid 22110, Jordan.
Laboratory for Development and Modelling of Novel Nanoporous Materials, Hamburg University of Technology, Eissendorfer Strasse 38, 21073 Hamburg, Germany.
Int J Biol Macromol. 2023 Jun 1;239:124238. doi: 10.1016/j.ijbiomac.2023.124238. Epub 2023 Mar 31.
Aerogels, especially bio-based ones, present a promising option for wound dressing; specifically, because of their low toxicity, high stability, bio-compatibility, and good biological performance. In this study, agar aerogel was prepared and evaluated as novel wound dressing material in an in vivo rat study. Agar hydrogel was prepared by thermal gelation, after that the water inside the gel was exchanged with ethanol, and finally the alcogel was dried by supercritical CO. The textural and rheological properties of the prepared aerogel were characterized, showing that the prepared agar aerogels possess high porosity (97-98 %), high surface area (250-330 mg) as well as good mechanical properties and easiness of removal from the wound site. The results of the in vivo experiments macroscopically demonstrate the tissue compatibility of the aerogels in dorsal interscapular injured rat tissue and a shorter wound healing time comparable to that of gauze-treated animals. The histological analysis underpins the reorganisation and healing of the tissue for the injured skin of rats treated with agar aerogel wound dressing within the studied time frame.
气凝胶，特别是基于生物的气凝胶，是一种很有前途的伤口敷料选择；特别是由于其低毒性、高稳定性、生物相容性和良好的生物学性能。在这项研究中，琼脂气凝胶被制备并作为新型伤口敷料材料在体内大鼠研究中进行了评估。通过热凝胶化制备琼脂水凝胶，然后将凝胶中的水用乙醇交换，最后用超临界 CO2 干燥 alcogel。对所制备的气凝胶的结构和流变性能进行了表征，结果表明所制备的琼脂气凝胶具有高孔隙率（97-98%）、高比表面积（250-330mg）以及良好的机械性能和易于从伤口部位去除。体内实验的结果宏观上证明了气凝胶在背部肩胛间受伤大鼠组织中的组织相容性，以及与用纱布处理的动物相比更短的伤口愈合时间。组织学分析支持了在研究时间范围内用琼脂气凝胶伤口敷料处理的受伤皮肤的组织重组和愈合。
