Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Medical Research Center, Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Mar Drugs. 2023 Jun 18;21(6):364. doi: 10.3390/md21060364.
Genital herpes is a common sexually transmitted disease mainly caused by herpes simplex virus type 2 (HSV-2), which can increase the risk of HIV transmission and is a major health problem in the world. Thus, it is of great significance to develop new anti-HSV-2 drugs with high efficiency and low toxicity. In this study, the anti-HSV-2 activities of PSSD, a marine sulfated polysaccharide, was deeply explored both in vitro and in vivo. The results showed that PSSD had marked anti-HSV-2 activities in vitro with low cytotoxicity. PSSD can directly interact with virus particles to inhibit the adsorption of virus to the cell surface. PSSD may also interact with virus surface glycoproteins to block virus-induced membrane fusion. Importantly, PSSD can significantly attenuate the symptoms of genital herpes and weight loss in mice after gel smear treatment, as well as reducing the titer of virus shedding in the reproductive tract of mice, superior to the effect of acyclovir. In summary, the marine polysaccharide PSSD possesses anti-HSV-2 effects both in vitro and in vivo, and has potential to be developed into a novel anti-genital herpes agent in the future.
生殖器疱疹是一种常见的性传播疾病，主要由单纯疱疹病毒 2 型（HSV-2）引起，它会增加 HIV 传播的风险，是全球主要的健康问题。因此，开发高效低毒的新型抗 HSV-2 药物具有重要意义。本研究深入探讨了海洋硫酸多糖 PSSD 的抗 HSV-2 活性，包括在体外和体内水平的研究。结果表明，PSSD 在体外具有显著的抗 HSV-2 活性，同时细胞毒性低。PSSD 可以直接与病毒颗粒相互作用，抑制病毒吸附到细胞表面。PSSD 还可能与病毒表面糖蛋白相互作用，阻断病毒诱导的膜融合。重要的是，PSSD 可以显著减轻生殖器疱疹小鼠的症状和体重减轻，以及减少生殖道中病毒脱落的滴度，优于阿昔洛韦的效果。综上所述，海洋多糖 PSSD 具有体外和体内的抗 HSV-2 作用，具有开发为新型抗生殖器疱疹药物的潜力。
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