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以及作为针对糖尿病大鼠模型的治疗剂——研究人IkB激酶药效团模型及与脱氢木香内酯分子相互作用的方法。

and as Therapeutic Agents against a Diabetic Rat Model-Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of .

作者信息

AlGeffari Metab A, Mansour Dina, Ahmed-Farid Omar, Mohamed Yousef Einas, Mohamed Shereen A, Moustafa Mahmoud M A, Barakat Hassan, Abd El Ghany Khalid

机构信息

Department of Family and Community Medicine, College of Medicine, Qassim University, Buraydah 51452, Saudi Arabia.

Diabetes Center, Medical City, Qassim University, Buraydah 51452, Saudi Arabia.

出版信息

Metabolites. 2023 Jun 19;13(6):764. doi: 10.3390/metabo13060764.

DOI:10.3390/metabo13060764
PMID:37367922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10302201/
Abstract

Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or is more effective in treating a diabetic rat model in a comparative study manner. An in vivo experiment was conducted to test the therapeutic activity of (MW719476.1) and plants against an alloxan-induced diabetic rat model. Molecular, biochemical, and histological analyses were investigated to evaluate the therapeutic characteristics of different treatments. The high dose of revealed the best downregulated expression for the , , , , , , , , , and genes compared to and the control groups. The downregulation of by could be attributed to dehydrocostus lactone as an active compound with proposed antidiabetic activity. So, we performed another pharmacophore modeling analysis to test the possible interaction between human IkB kinase beta protein and dehydrocostus lactone as an antidiabetic drug. Molecular docking and MD simulation data confirmed the interaction between human IkB kinase beta protein and dehydrocostus lactone as a possible drug. The target genes are important in regulating type 2 diabetes mellitus signaling, lipid and atherosclerosis signaling, NF-κB signaling, and IL-17 signaling pathways. In conclusion, the plant could be a promising source of novel therapeutic agents for treating diabetes and its complications. Dehydrocostus lactone caused the ameliorative effect of by its interaction with human IkB kinase beta protein. Further, future studies could be conducted to find the clinical efficacy of dehydrocostus lactone.

摘要

乳酸菌作为缓解或预防糖尿病的重要策略而广为人知。同样，植物（Falc）Lipsch对糖尿病也具有预防作用。在此，我们旨在通过比较研究的方式确定乳酸菌或该植物在治疗糖尿病大鼠模型中哪种更有效。进行了一项体内实验，以测试（MW719476.1）和该植物对四氧嘧啶诱导的糖尿病大鼠模型的治疗活性。进行了分子、生化和组织学分析，以评估不同治疗方法的治疗特性。与该植物和对照组相比，高剂量的该植物对、、、、、、、、和基因的表达下调效果最佳。该植物对的下调可能归因于脱氢木香内酯，它是一种具有抗糖尿病活性的活性化合物。因此，我们进行了另一项药效团建模分析，以测试人IkB激酶β蛋白与作为抗糖尿病药物的脱氢木香内酯之间可能的相互作用。分子对接和分子动力学模拟数据证实了人IkB激酶β蛋白与脱氢木香内酯之间的相互作用，表明其可能是一种药物。这些靶基因在调节2型糖尿病信号传导、脂质和动脉粥样硬化信号传导、NF-κB信号传导和IL-17信号通路中很重要。总之，该植物可能是治疗糖尿病及其并发症的新型治疗剂的有希望的来源。脱氢木香内酯通过与人IkB激酶β蛋白相互作用而产生该植物对糖尿病的改善作用。此外，未来可以进行研究以发现脱氢木香内酯的临床疗效。

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