• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

带正电荷的聚-L-赖氨酸磁性纳米颗粒作为潜在磁共振成像造影剂的研发

Development of Positively Charged Poly-L-Lysine Magnetic Nanoparticles as Potential MRI Contrast Agent.

作者信息

Antal Iryna, Strbak Oliver, Zavisova Vlasta, Vojtova Jana, Kubovcikova Martina, Jurikova Alena, Khmara Iryna, Girman Vladimir, Džunda Róbert, Kovaľ Karol, Koneracka Martina

机构信息

Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001 Kosice, Slovakia.

Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 03601 Martin, Slovakia.

出版信息

Nanomaterials (Basel). 2023 Jun 9;13(12):1831. doi: 10.3390/nano13121831.

DOI:10.3390/nano13121831
PMID:37368261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10305316/
Abstract

A colloidal solution of magnetic nanoparticles (MNPs) modified with biocompatible positively charged poly-L-lysine (PLL) with an oleate (OL) layer employed as an initial coating was produced as a potential MRI contrast agent. The effect of various PLL/MNPs' mass ratios on the samples' hydrodynamic diameter, zeta potential, and isoelectric point (IEP) was studied by the dynamic light-scattering method. The optimal mass ratio for MNPs' surface coating was 0.5 (sample PLL-OL-MNPs). The average hydrodynamic particle size in the sample of PLL-OL-MNPs was 124.4 ± 1.4 nm, and in the PLL-unmodified nanoparticles, it was 60.9 ± 0.2 nm, indicating that the OL-MNPs' surface became covered by PLL. Next, the typical characteristics of the superparamagnetic behavior were observed in all samples. In addition, the decrease in saturation magnetizations from 66.9 Am/kg for MNPs to 35.9 and 31.6 Am/kg for sample OL-MNPs and PLL-OL-MNPs also confirmed successful PLL adsorption. Moreover, we show that both OL-MNPs and PLL-OL-MNPs exhibit excellent MRI relaxivity properties and a very high ratio, which is very desirable in biomedical applications with required MRI contrast enhancement. The PLL coating itself appears to be the crucial factor in enhancing the relaxivity of MNPs in MRI relaxometry.

摘要

制备了一种磁性纳米颗粒（MNP）的胶体溶液，该纳米颗粒用生物相容性带正电的聚-L-赖氨酸（PLL）修饰，并以油酸盐（OL）层作为初始涂层，用作潜在的磁共振成像（MRI）造影剂。通过动态光散射法研究了各种PLL/MNP质量比对样品流体动力学直径、zeta电位和等电点（IEP）的影响。MNP表面涂层的最佳质量比为0.5（样品PLL-OL-MNP）。PLL-OL-MNP样品中的平均流体动力学粒径为124.4±1.4nm，而在未修饰PLL的纳米颗粒中为60.9±0.2nm，这表明OL-MNP的表面被PLL覆盖。接下来，在所有样品中都观察到了超顺磁行为的典型特征。此外，饱和磁化强度从MNP的66.9Am/kg降至样品OL-MNP和PLL-OL-MNP的35.9和31.6Am/kg，这也证实了PLL的成功吸附。此外，我们表明，OL-MNP和PLL-OL-MNP都表现出优异的MRI弛豫性能和非常高的 比，这在需要增强MRI对比度的生物医学应用中是非常理想的。在MRI弛豫测量中，PLL涂层本身似乎是提高MNP弛豫率的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/fb02ff65ae6f/nanomaterials-13-01831-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/5cb49ace67e0/nanomaterials-13-01831-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/afe5a5301797/nanomaterials-13-01831-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/efe338668d2c/nanomaterials-13-01831-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/0c3bdf342b8d/nanomaterials-13-01831-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/fe41e203a051/nanomaterials-13-01831-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/0b3d2f6552b3/nanomaterials-13-01831-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/61c2130a2957/nanomaterials-13-01831-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/bd8632799401/nanomaterials-13-01831-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/c5e8f105a5b0/nanomaterials-13-01831-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/2e67644311af/nanomaterials-13-01831-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/e5b654d33216/nanomaterials-13-01831-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/18be7a58461d/nanomaterials-13-01831-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/8da27dd53907/nanomaterials-13-01831-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/cec518522bc0/nanomaterials-13-01831-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/fb02ff65ae6f/nanomaterials-13-01831-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/5cb49ace67e0/nanomaterials-13-01831-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/afe5a5301797/nanomaterials-13-01831-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/efe338668d2c/nanomaterials-13-01831-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/0c3bdf342b8d/nanomaterials-13-01831-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/fe41e203a051/nanomaterials-13-01831-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/0b3d2f6552b3/nanomaterials-13-01831-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/61c2130a2957/nanomaterials-13-01831-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/bd8632799401/nanomaterials-13-01831-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/c5e8f105a5b0/nanomaterials-13-01831-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/2e67644311af/nanomaterials-13-01831-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/e5b654d33216/nanomaterials-13-01831-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/18be7a58461d/nanomaterials-13-01831-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/8da27dd53907/nanomaterials-13-01831-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/cec518522bc0/nanomaterials-13-01831-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e753/10305316/fb02ff65ae6f/nanomaterials-13-01831-g014.jpg

相似文献

1
Development of Positively Charged Poly-L-Lysine Magnetic Nanoparticles as Potential MRI Contrast Agent.带正电荷的聚-L-赖氨酸磁性纳米颗粒作为潜在磁共振成像造影剂的研发
Nanomaterials (Basel). 2023 Jun 9;13(12):1831. doi: 10.3390/nano13121831.
2
Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate.铕取代对锰锌铁氧体纳米颗粒的结构、磁性和弛豫性能的影响：一种双模式磁共振成像造影剂候选物。
Nanomaterials (Basel). 2023 Jan 12;13(2):331. doi: 10.3390/nano13020331.
3
Synthesis and characterization of modified magnetic nanoparticles as theranostic agents: in vitro safety assessment in healthy cells.改性磁性纳米粒子作为治疗诊断一体化试剂的合成与表征：在健康细胞中的体外安全性评估。
Toxicol In Vitro. 2021 Apr;72:105094. doi: 10.1016/j.tiv.2021.105094. Epub 2021 Jan 15.
4
Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells.多聚赖氨酸涂层与硫酸乙酰肝素蛋白聚糖对肿瘤细胞摄取磁性纳米颗粒的相互作用。
Int J Nanomedicine. 2018 Mar 20;13:1693-1706. doi: 10.2147/IJN.S156029. eCollection 2018.
5
MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings.不同氨基酸涂层诱导的磁性纳米颗粒的磁共振成像弛豫率变化
Nanomaterials (Basel). 2020 Feb 24;10(2):394. doi: 10.3390/nano10020394.
6
Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling.用于干细胞标记的聚（L-赖氨酸）修饰的氧化铁纳米颗粒
Bioconjug Chem. 2008 Mar;19(3):740-50. doi: 10.1021/bc700410z. Epub 2008 Feb 21.
7
-Acetylcysteine-Loaded Magnetic Nanoparticles for Magnetic Resonance Imaging.载乙酰半胱氨酸的磁性纳米颗粒用于磁共振成像。
Int J Mol Sci. 2023 Jul 13;24(14):11414. doi: 10.3390/ijms241411414.
8
Monolayers of poly-L-lysine on mica--Electrokinetic characteristics.云母上的聚-L-赖氨酸单层——动电特性。
J Colloid Interface Sci. 2015 Oct 15;456:116-24. doi: 10.1016/j.jcis.2015.05.044. Epub 2015 Jun 9.
9
Facile Synthesis, Static, and Dynamic Magnetic Characteristics of Varying Size Double-Surfactant-Coated Mesoscopic Magnetic Nanoparticles Dispersed Stable Aqueous Magnetic Fluids.不同尺寸双表面活性剂包覆的介观磁性纳米颗粒分散稳定水基磁流体的简易合成、静态和动态磁特性
Nanomaterials (Basel). 2021 Nov 9;11(11):3009. doi: 10.3390/nano11113009.
10
PEGylation of Superparamagnetic Iron Oxide Nanoparticles with Self-Organizing Polyacrylate-PEG Brushes for Contrast Enhancement in MRI Diagnosis.用于磁共振成像诊断中增强造影的具有自组装聚丙烯酸酯-聚乙二醇刷的超顺磁性氧化铁纳米颗粒的聚乙二醇化
Nanomaterials (Basel). 2018 Sep 29;8(10):776. doi: 10.3390/nano8100776.

引用本文的文献

1
Spatial Topological Structure Design of Porous Ti-6Al-4V Alloy with Low Modulus and Magnetic Susceptibility.具有低模量和低磁化率的多孔Ti-6Al-4V合金的空间拓扑结构设计
Nanomaterials (Basel). 2023 Dec 11;13(24):3113. doi: 10.3390/nano13243113.

本文引用的文献

1
L-Lysine-Coated Magnetic Core-Shell Nanoparticles for the Removal of Acetylsalicylic Acid from Aqueous Solutions.用于从水溶液中去除乙酰水杨酸的L-赖氨酸包覆的磁性核壳纳米颗粒
Nanomaterials (Basel). 2023 Jan 27;13(3):514. doi: 10.3390/nano13030514.
2
Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications.葡聚糖分子量对用于热疗和磁共振成像的磁性纳米颗粒物理性质的影响
Nanomaterials (Basel). 2020 Dec 9;10(12):2468. doi: 10.3390/nano10122468.
3
MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings.
不同氨基酸涂层诱导的磁性纳米颗粒的磁共振成像弛豫率变化
Nanomaterials (Basel). 2020 Feb 24;10(2):394. doi: 10.3390/nano10020394.
4
Amino Acid Functionalized Superparamagnetic Nanoparticles Inhibit Lysozyme Amyloid Fibrillization.氨基酸功能化超顺磁性纳米粒子抑制溶菌酶淀粉样纤维形成。
Chemistry. 2019 Jun 4;25(31):7501-7514. doi: 10.1002/chem.201806262. Epub 2019 May 9.
5
Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.粒径和多分散指数对脂质纳米载体系统临床应用的影响
Pharmaceutics. 2018 May 18;10(2):57. doi: 10.3390/pharmaceutics10020057.
6
d,l-lysine functionalized FeO nanoparticles for detection of cancer cells.d,l-赖氨酸功能化 FeO 纳米颗粒用于癌细胞检测。
Colloids Surf B Biointerfaces. 2018 Mar 1;163:236-245. doi: 10.1016/j.colsurfb.2017.12.022. Epub 2017 Dec 21.
7
Aggregation and Colloidal Stability of Commercially Available Al₂O₃ Nanoparticles in Aqueous Environments.市售氧化铝纳米颗粒在水性环境中的聚集与胶体稳定性
Nanomaterials (Basel). 2016 May 13;6(5):90. doi: 10.3390/nano6050090.
8
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents.极其微小的氧化铁纳米颗粒作为阳性磁共振成像造影剂。
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2325-2330. doi: 10.1073/pnas.1620145114. Epub 2017 Feb 13.
9
Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents.磁共振成像中的纳米颗粒：从简单造影剂到双功能造影剂
Int J Nanomedicine. 2015 Mar 6;10:1727-41. doi: 10.2147/IJN.S76501. eCollection 2015.
10
Acoustic wave in a suspension of magnetic nanoparticle with sodium oleate coating.具有油酸钠涂层的磁性纳米颗粒悬浮液中的声波。
J Nanopart Res. 2014;16(3):2271. doi: 10.1007/s11051-014-2271-z. Epub 2014 Feb 5.