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不同氨基酸涂层诱导的磁性纳米颗粒的磁共振成像弛豫率变化

MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings.

作者信息

Antal Iryna, Strbak Oliver, Khmara Iryna, Koneracka Martina, Kubovcikova Martina, Zavisova Vlasta, Kmetova Martina, Baranovicova Eva, Dobrota Dusan

机构信息

Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia.

Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia.

出版信息

Nanomaterials (Basel). 2020 Feb 24;10(2):394. doi: 10.3390/nano10020394.

DOI:10.3390/nano10020394
PMID:32102280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075310/
Abstract

In this study, we analysed the physico-chemical properties of positively charged magnetic fluids consisting of magnetic nanoparticles (MNPs) functionalised by different amino acids (AAs): glycine (Gly), lysine (Lys) and tryptophan (Trp), and the influence of AA-MNP complexes on the MRI relaxivity. We found that the AA coating affects the size of dispersed particles and isoelectric point, as well as the zeta potential of AA-MNPs differently, depending on the AA selected. Moreover, we showed that a change in hydrodynamic diameter results in a change to the relaxivity of AA-MNP complexes. On the one hand, we observed a decrease in the relaxivity values, and , with an increase in hydrodynamic diameter (the relaxivity of and were comparable with commercially available contrast agents); on the other hand, we observed an increase in * value with an increase in hydrodynamic size. These findings provide an interesting preliminary look at the impact of AA coating on the relaxivity properties of AA-MNP complexes, with a specific application in molecular contrast imaging originating from magnetic nanoparticles and magnetic resonance techniques.

摘要

在本研究中，我们分析了由不同氨基酸（AA）功能化的磁性纳米颗粒（MNP）组成的带正电磁性流体的物理化学性质，这些氨基酸包括甘氨酸（Gly）、赖氨酸（Lys）和色氨酸（Trp），以及AA-MNP复合物对磁共振成像（MRI）弛豫率的影响。我们发现，根据所选的AA不同，AA包被对分散颗粒的大小、等电点以及AA-MNP的zeta电位有不同影响。此外，我们表明流体动力学直径的变化会导致AA-MNP复合物弛豫率的改变。一方面，我们观察到随着流体动力学直径的增加，弛豫率值 和 降低（ 和 的弛豫率与市售造影剂相当）；另一方面，我们观察到随着流体动力学尺寸的增加，*值增加。这些发现为AA包被对AA-MNP复合物弛豫率性质的影响提供了有趣的初步观察结果，在源自磁性纳米颗粒和磁共振技术的分子对比成像中有特定应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/29e7764a17ac/nanomaterials-10-00394-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/fcbd3258fa3f/nanomaterials-10-00394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/b46f3e0d5b3e/nanomaterials-10-00394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/d0b3ef42e0f1/nanomaterials-10-00394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/b53b0c4ca378/nanomaterials-10-00394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/bd077a6f6614/nanomaterials-10-00394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/d4a016f384ec/nanomaterials-10-00394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/3da6d833647c/nanomaterials-10-00394-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/bb4ab5bf4379/nanomaterials-10-00394-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/25aba45c0107/nanomaterials-10-00394-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/39334fbc489c/nanomaterials-10-00394-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/29d85d60e057/nanomaterials-10-00394-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/f791e2f0216c/nanomaterials-10-00394-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/58e9f3a3efd0/nanomaterials-10-00394-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/8eed497ae7af/nanomaterials-10-00394-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/29e7764a17ac/nanomaterials-10-00394-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/fcbd3258fa3f/nanomaterials-10-00394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/b46f3e0d5b3e/nanomaterials-10-00394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/d0b3ef42e0f1/nanomaterials-10-00394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/b53b0c4ca378/nanomaterials-10-00394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/bd077a6f6614/nanomaterials-10-00394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/d4a016f384ec/nanomaterials-10-00394-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/3da6d833647c/nanomaterials-10-00394-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/bb4ab5bf4379/nanomaterials-10-00394-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/25aba45c0107/nanomaterials-10-00394-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/39334fbc489c/nanomaterials-10-00394-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/29d85d60e057/nanomaterials-10-00394-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/f791e2f0216c/nanomaterials-10-00394-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/58e9f3a3efd0/nanomaterials-10-00394-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/8eed497ae7af/nanomaterials-10-00394-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b9/7075310/29e7764a17ac/nanomaterials-10-00394-g015.jpg

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