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Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1.

作者信息

Jin Xiaohuan, Guan Zeyuan, Hu Na, He Chunjie, Yin Ping, Gong Zhou, Zhang Delin

机构信息

National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei, China.

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences, Wuhan, Hubei, China.

出版信息

Cell Discov. 2023 Jun 27;9(1):65. doi: 10.1038/s41421-023-00562-y.

DOI:10.1038/s41421-023-00562-y
PMID:37369656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10300002/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/10300002/b9bd6afbb65b/41421_2023_562_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/10300002/b9bd6afbb65b/41421_2023_562_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39b/10300002/b9bd6afbb65b/41421_2023_562_Fig1_HTML.jpg

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2
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Nature. 2023 Jan;613(7943):383-390. doi: 10.1038/s41586-022-05565-5. Epub 2023 Jan 4.
3
N-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
PLoS Pathog. 2025 Apr 21;21(4):e1013120. doi: 10.1371/journal.ppat.1013120. eCollection 2025 Apr.
4
Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases.METTL1/WDR4和QKI作为m7G修饰相关酶在消化系统疾病中的作用。
Front Pharmacol. 2025 Jan 9;15:1491763. doi: 10.3389/fphar.2024.1491763. eCollection 2024.
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Pathogenic mechanism and therapeutic intervention of impaired N-methylguanosine (mG) tRNA modification.异常 N-甲基鸟苷（mG）tRNA 修饰的致病机制与治疗干预。
Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2405886121. doi: 10.1073/pnas.2405886121. Epub 2024 Oct 29.
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Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5.
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