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MBD3作为结肠癌的潜在生物标志物：对上皮-间质转化（EMT）途径的影响

MBD3 as a Potential Biomarker for Colon Cancer: Implications for Epithelial-Mesenchymal Transition (EMT) Pathways.

作者信息

Ding Yuntao, Wang Huizhi, Liu Junqiang, Jiang Han, Gong Aihua, Xu Min

机构信息

Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212000, China.

Hematological Disease Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.

出版信息

Cancers (Basel). 2023 Jun 14;15(12):3185. doi: 10.3390/cancers15123185.

DOI:10.3390/cancers15123185
PMID:37370795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10296356/
Abstract

The tumor EMT is a crucial event in tumor pathogenesis and progression. Previous research has established MBD3's significant role in pancreatic cancer EMT. However, MBD3's precise role in colon cancer remains unclear and warrants further investigation. Pan-cancer analysis revealed MBD3's differential expression in various tumors and its significant association with tumor occurrence, growth, and progression. Moreover, analysis of single-cell sequencing and clinical data for colon cancer revealed MBD3 expression's negative correlation with clinical indicators such as survival prognosis. Functional enrichment analysis confirmed the association between MBD3 and EMT in colon cancer. Pathological examinations, western blotting, and qRT-PCR in vitro and in vivo validated MBD3's differential expression in colon cancer. Transwell, CCK-8, clone formation, and in vivo tumorigenesis experiments confirmed MBD3's impact on migration, invasion, and proliferation. Our findings demonstrate MBD3 as a potential prognostic marker and therapeutic target for colon cancer.

摘要

肿瘤上皮-间质转化（EMT）是肿瘤发生发展过程中的关键事件。以往研究已证实MBD3在胰腺癌EMT中具有重要作用。然而，MBD3在结肠癌中的具体作用仍不清楚，值得进一步研究。泛癌分析揭示了MBD3在各种肿瘤中的差异表达及其与肿瘤发生、生长和进展的显著关联。此外，对结肠癌单细胞测序和临床数据的分析显示，MBD3表达与生存预后等临床指标呈负相关。功能富集分析证实了MBD3与结肠癌EMT之间的关联。体内外病理检查、蛋白质免疫印迹法和qRT-PCR验证了MBD3在结肠癌中的差异表达。Transwell、CCK-8、克隆形成和体内肿瘤发生实验证实了MBD3对迁移、侵袭和增殖的影响。我们的研究结果表明，MBD3是结肠癌潜在的预后标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/ea3dba62668c/cancers-15-03185-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/c2a6377c6ec2/cancers-15-03185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/48c340fcf4b4/cancers-15-03185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/555306b14614/cancers-15-03185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/7e90ef0d5700/cancers-15-03185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/9ef83ff53c3b/cancers-15-03185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/2f5f107002c4/cancers-15-03185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/ea3dba62668c/cancers-15-03185-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/c2a6377c6ec2/cancers-15-03185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/48c340fcf4b4/cancers-15-03185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/555306b14614/cancers-15-03185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/7e90ef0d5700/cancers-15-03185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/9ef83ff53c3b/cancers-15-03185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/2f5f107002c4/cancers-15-03185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c222/10296356/ea3dba62668c/cancers-15-03185-g007.jpg

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