Ullah Fauzia, Pillai Ashwathy Balachandran, Omar Najiullah, Dima Danai, Harichand Seema
Department of Translational Hematology and Oncology Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancers (Basel). 2023 Jun 15;15(12):3202. doi: 10.3390/cancers15123202.
Over the past decade, the incidence of colorectal cancer has increased in individuals under the age of 50 years. Meanwhile, the incidence has gradually decreased in the older population. As described herein, we reviewed the available literature to summarize the current landscape of early-onset colorectal cancer, including risk factors, clinicopathological presentation, genetic makeup of patients, and management. Currently, early-onset colorectal cancer is treated similarly as late-onset colorectal cancer, yet the available literature shows that early-onset colorectal cancer is more aggressive and different, and this remains a significant unmet need. A detailed understanding of early-onset colorectal cancer is needed to identify risk factors for the increased incidence and tailor treatments accordingly.
在过去十年中，50岁以下人群的结直肠癌发病率有所上升。与此同时，老年人群中的发病率则逐渐下降。如本文所述，我们回顾了现有文献，以总结早发性结直肠癌的现状，包括危险因素、临床病理表现、患者的基因构成以及治疗方法。目前，早发性结直肠癌的治疗方式与晚发性结直肠癌相似，但现有文献表明，早发性结直肠癌更具侵袭性且有所不同，这仍是一个重大的未满足需求。需要对早发性结直肠癌有详细的了解，以确定发病率上升的危险因素并据此调整治疗方案。
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