School of Psychology, Beijing Sport University, Beijing 100084, China.
The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Neurobiol Learn Mem. 2022 Jul;192:107625. doi: 10.1016/j.nlm.2022.107625. Epub 2022 Apr 30.
We aimed to explore whether modafinil mitigates the working memory decline induced by 36 h of acute total sleep deprivation (36-h TSD). Sixteen healthy male participants were enrolled in a randomized double-blind crossover control study involving three sleep-deprivation sessions. Participants were administered 400 mg of placebo, caffeine, or modafinil during these sessions. Behavior and EEG data were recorded while participants performed pronunciation-related working memory tasks. Behavioral indicators showed that, compared with placebo, modafinil improved the accuracy of pronunciation-related working memory tasks and reduced the response time. Compared with before sleep deprivation, the amplitudes of the event-related potentials (ERPs) increased in the N2 component and decreased in the P3 component after sleep deprivation in the placebo condition. In the caffeine condition, the amplitude of the P3 component decreased, the latency of the N2 component was prolonged, and the N2 amplitude remained unchanged. In the modafinil condition, the P3 latency was shortened, and no significant difference was found in the amplitude of the N2 or P3 ERPs; no significant difference was recorded in the N2 latency. Modafinil (400 mg) effectively ameliorated the decline in pronunciation-related working memory after 36-h TSD, suggesting that it may effectively counteract cognitive decline caused by acute sleep deprivation.
我们旨在探讨莫达非尼是否能减轻 36 小时急性完全睡眠剥夺（36-h TSD）引起的工作记忆下降。16 名健康男性参与者被纳入一项随机、双盲、交叉对照研究，涉及三个睡眠剥夺阶段。在这些阶段中，参与者接受 400mg 的安慰剂、咖啡因或莫达非尼治疗。当参与者执行与发音相关的工作记忆任务时，记录行为和 EEG 数据。行为指标表明，与安慰剂相比，莫达非尼提高了与发音相关的工作记忆任务的准确性，同时缩短了反应时间。与睡眠剥夺前相比，在安慰剂条件下，睡眠剥夺后事件相关电位（ERPs）的 N2 成分的振幅增加，P3 成分的振幅减小。在咖啡因条件下，P3 成分的振幅减小，N2 成分的潜伏期延长，N2 振幅保持不变。在莫达非尼条件下，P3 潜伏期缩短，N2 或 P3 ERP 的振幅没有显著差异；N2 潜伏期也没有记录到显著差异。莫达非尼（400mg）有效改善了 36-h TSD 后与发音相关的工作记忆下降，表明其可能有效对抗急性睡眠剥夺引起的认知能力下降。
