Turri Chiara, Di Dona Giuseppe, Santoni Alessia, Zamfira Denisa Adina, Franchin Laura, Melcher David, Ronconi Luca
School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Biomedicines. 2023 Jun 1;11(6):1607. doi: 10.3390/biomedicines11061607.
Developmental Dyslexia (DD) is a neurobiological condition affecting the ability to read fluently and/or accurately. Analyzing resting-state electroencephalographic (EEG) activity in DD may provide a deeper characterization of the underlying pathophysiology and possible biomarkers. So far, studies investigating resting-state activity in DD provided limited evidence and did not consider the aperiodic component of the power spectrum. In the present study, adults with ( = 26) and without DD ( = 31) underwent a reading skills assessment and resting-state EEG to investigate potential alterations in aperiodic activity, their impact on the periodic counterpart and reading performance. In parieto-occipital channels, DD participants showed a significantly different aperiodic activity as indexed by a flatter and lower power spectrum. These aperiodic measures were significantly related to text reading time, suggesting a link with individual differences in reading difficulties. In the beta band, the DD group showed significantly decreased aperiodic-adjusted power compared to typical readers, which was significantly correlated to word reading accuracy. Overall, here we provide evidence showing alterations of the endogenous aperiodic activity in DD participants consistently with the increased neural noise hypothesis. In addition, we confirm alterations of endogenous beta rhythms, which are discussed in terms of their potential link with magnocellular-dorsal stream deficit.
发育性阅读障碍（DD）是一种影响流畅和/或准确阅读能力的神经生物学病症。分析DD患者静息状态下的脑电图（EEG）活动可能有助于更深入地了解潜在的病理生理学特征和可能的生物标志物。到目前为止，关于DD患者静息状态活动的研究提供的证据有限，并且没有考虑功率谱的非周期性成分。在本研究中，26名患有DD的成年人和31名未患DD的成年人接受了阅读技能评估和静息状态EEG检查，以研究非周期性活动的潜在变化、其对周期性活动的影响以及阅读表现。在顶枕通道中，DD参与者表现出明显不同的非周期性活动，其指标是功率谱更平坦且更低。这些非周期性测量结果与文本阅读时间显著相关，表明与阅读困难的个体差异存在关联。在β波段，与典型阅读者相比，DD组的非周期性调整功率显著降低，这与单词阅读准确性显著相关。总体而言，我们在此提供的证据表明，DD参与者内源性非周期性活动的改变与神经噪声增加假说一致。此外，我们证实了内源性β节律的改变，并根据其与大细胞背侧流缺陷的潜在联系进行了讨论。
