Key Laboratory for Genetic Improvement of Indigenous Chicken Breeds of Jiangxi Province, Nanchang Normal University, Nanchang 330032, China.
Genes (Basel). 2023 May 30;14(6):1198. doi: 10.3390/genes14061198.
The emergence of high-throughput sequencing technology promotes life science development, provides technical support to analyze many life mechanisms, and presents new solutions to previously unsolved problems in genomic research. Resequencing technology has been widely used for genome selection and research on chicken population structure, genetic diversity, evolutionary mechanisms, and important economic traits caused by genome sequence differences since the release of chicken genome sequence information. This article elaborates on the factors influencing whole genome resequencing and the differences between these factors and whole genome sequencing. It reviews the important research progress in chicken qualitative traits (e.g., frizzle feather and comb), quantitative traits (e.g., meat quality and growth traits), adaptability, and disease resistance, and provides a theoretical basis to study whole genome resequencing in chickens.
高通量测序技术的出现推动了生命科学的发展，为分析许多生命机制提供了技术支持，并为基因组研究中以前尚未解决的问题提供了新的解决方案。自鸡基因组序列信息发布以来，重测序技术已广泛应用于基因组选择和鸡群体结构、遗传多样性、进化机制以及由基因组序列差异引起的重要经济性状的研究。本文阐述了影响全基因组重测序的因素以及这些因素与全基因组测序的区别，综述了鸡重要的质量性状（如卷毛和鸡冠）、数量性状（如肉质和生长性状）、适应性和抗病性的重要研究进展，为研究鸡的全基因组重测序提供了理论依据。
