National Research Council of Italy, Institute of Neuroscience, Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy.
Int J Mol Sci. 2023 Jun 6;24(12):9805. doi: 10.3390/ijms24129805.
Extensive evidence indicates that the activation of the P2X receptor (P2XR), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2XR-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2XR activation on extracellular vesicle release and their activities.
大量证据表明，P2X 受体（P2XR）的激活与细胞外囊泡的释放密切相关，P2XR 是一种在免疫细胞和脑细胞中高度表达的 ATP 门控离子通道。通过这个过程，表达 P2XR 的细胞调节非经典的蛋白质分泌，并将生物活性成分转移到其他细胞，包括错误折叠的蛋白质，参与炎症和神经退行性疾病。在这篇综述中，我们总结和讨论了研究 P2XR 激活对细胞外囊泡释放及其活性的影响。
