Second Department of Obstetrics and Gynaecology, Aretaieion University Hospital, National and Kapodistrian University of Athens Medical School, 115 28 Athens, Greece.
Int J Mol Sci. 2023 Jun 6;24(12):9828. doi: 10.3390/ijms24129828.
Female infertility and reproduction is an ongoing and rising healthcare issue, resulting in delaying the decision to start a family. Therefore, in this review, we examine potential novel metabolic mechanisms involved in ovarian aging according to recent data and how these mechanisms may be addressed through new potential medical treatments. We examine novel medical treatments currently available based mostly on experimental stem cell procedures as well as caloric restriction (CR), hyperbaric oxygen treatment and mitochondrial transfer. Understanding the connection between metabolic and reproductive pathways has the potential to offer a significant scientific breakthrough in preventing ovarian aging and prolonging female fertility. Overall, the field of ovarian aging is an emerging field that may expand the female fertility window and perhaps even reduce the need for artificial reproductive techniques.
女性不孕和生殖是一个持续存在且不断上升的医疗保健问题，导致人们延迟了组建家庭的决定。因此，在这篇综述中，我们根据最新数据研究了卵巢衰老过程中涉及的潜在新型代谢机制，以及这些机制如何通过新的潜在医学治疗方法来解决。我们研究了目前基于实验性干细胞程序以及热量限制（CR）、高压氧治疗和线粒体转移的新型医学治疗方法。理解代谢和生殖途径之间的联系有可能为预防卵巢衰老和延长女性生育能力提供重大的科学突破。总的来说，卵巢衰老领域是一个新兴领域，它可能会扩大女性生育窗口，甚至可能减少对人工生殖技术的需求。
