胚系能量学、衰老与女性不孕。
Germline energetics, aging, and female infertility.
机构信息
Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA.
Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
出版信息
Cell Metab. 2013 Jun 4;17(6):838-850. doi: 10.1016/j.cmet.2013.05.007.
Abstract
The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.
摘要
尽管卵巢比大多数其他器官更早衰竭，但代谢在卵巢衰老中的作用仍描述不足。最近有证据表明，哺乳动物雌性在成年期通过生殖干细胞的活性定期产生新的卵母细胞，这激发了人们对卵巢功能的兴趣。从这个角度来看，我们将女性生殖系统视为一个强大且具有临床相关性的模型，以了解衰老和代谢之间的联系，并讨论卵母细胞及其前体细胞如何在代谢上发生改变以维持或增加女性的卵巢功能和生育能力的新概念。
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