Ghobrial Stefan, Ott Johannes, Steininger Johanna, Dewailly Didier, Prager Gerhard
Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Faculty of Medicine, University of Lille, 59000 Lille, France.
J Clin Med. 2023 Jun 9;12(12):3940. doi: 10.3390/jcm12123940.
Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is associated with obesity. The most effective method to achieve and maintain long-term weight loss is by the Roux-en-Y gastric bypass (RYGB). In this review, an overview about metabolic and PCOS-specific outcomes after RYGB in obese PCOS women is provided. The RYGB leads to an adequate excess weight loss and reduction in BMI in this patient population. Testosterone levels decline significantly at 6- and 12-months follow-up, as does the incidence of hirsutism and cycle irregularities. Data about fertility are scarce in this patient population. In conclusion, RYGB surgery seems to be an efficient treatment option for obese PCOS patients and leads to weight loss and improvements in metabolic parameters as well as in an improvement of PCOS-specific characteristics. However, larger prospective studies are warranted, which include all PCOS-specific outcome data in one patient population at the same time.
多囊卵巢综合征（PCOS）是育龄女性最常见的内分泌疾病，与肥胖有关。实现并维持长期体重减轻的最有效方法是胃旁路手术（RYGB）。在本综述中，概述了肥胖PCOS女性接受RYGB术后的代谢及PCOS特异性结局。RYGB可使该患者群体实现充分的体重减轻并降低体重指数。在6个月和12个月随访时，睾酮水平显著下降，多毛症和月经周期不规律的发生率也显著下降。该患者群体中关于生育力的数据较少。总之，RYGB手术似乎是肥胖PCOS患者的一种有效治疗选择，可导致体重减轻、代谢参数改善以及PCOS特异性特征的改善。然而，需要开展更大规模的前瞻性研究，同时纳入同一患者群体的所有PCOS特异性结局数据。
