Marolo Paola, Borrelli Enrico, Gelormini Francesco, Boscia Giacomo, Parisi Guglielmo, Fallico Matteo, Barresi Costanza, Lari Giorgio, Berni Alessandro, Bandello Francesco, Reibaldi Michele
Department of Ophthalmology, University of Turin, 10126 Turin, Italy.
Ophthalmology Department, Vita-Salute San Raffaele University, 20132 Milan, Italy.
J Clin Med. 2023 Jun 11;12(12):3976. doi: 10.3390/jcm12123976.
(1) Purpose: To determine the "retinal thickness deviation" (RTD) in diabetic macular edema (DME) eyes treated with intravitreal therapy and to establish associations between RTD and best-corrected visual acuity (BCVA). (2) Methods: We conducted a retrospective study, including consecutive patients with DME eyes undergoing intravitreal therapy with two years of follow-up. BCVA and central subfield thickness (CST) were collected at baseline and at 12 months and 24 months of follow-up. RTD was calculated as the absolute difference between measured and normative CST values at each time point. Linear regression analyses were performed between RTD and BCVA and between CST and BCVA. (3) Results: One hundred and four eyes were included in the analysis. The RTD was 177.0 (117.2) μm at baseline, 97.0 (99.7) μm at 12 months and 89.9 (75.3) μm at 24 months of follow-up ( < 0.001). RTD showed a moderate association with BCVA at baseline (R = 0.134, < 0.001) and 12 months (R = 0.197, < 0.001) and a substantial association at 24 months (R = 0.272, < 0.001). The CST showed a moderate association with BCVA at baseline (R = 0.132, < 0.001) and 12 months (R = 0.136, < 0.001), while the association was weak at 24 months (R = 0.065, = 0.009). (4) Conclusions: RTD showed a good association with visual outcome in patients with DME eyes undergoing intravitreal treatment.
(1) 目的：确定接受玻璃体腔内治疗的糖尿病性黄斑水肿（DME）眼的“视网膜厚度偏差”（RTD），并建立RTD与最佳矫正视力（BCVA）之间的关联。(2) 方法：我们进行了一项回顾性研究，纳入连续接受玻璃体腔内治疗且随访两年的DME眼患者。在基线、随访12个月和24个月时收集BCVA和中心子野厚度（CST）。RTD计算为每个时间点测量的CST值与正常CST值之间的绝对差值。对RTD与BCVA之间以及CST与BCVA之间进行线性回归分析。(3) 结果：104只眼纳入分析。随访基线时RTD为177.0（117.2）μm，12个月时为97.0（99.7）μm，24个月时为89.9（75.3）μm（<0.001）。RTD在基线时与BCVA呈中度关联（R = 0.134，<0.001），12个月时呈中度关联（R = 0.197，<0.001），24个月时呈显著关联（R = 0.272，<0.001）。CST在基线时与BCVA呈中度关联（R = 0.132，<0.001），12个月时呈中度关联（R = 0.136，<0.001），而在24个月时关联较弱（R = 0.065，= 0.009）。(4) 结论：RTD与接受玻璃体腔内治疗的DME眼患者的视力预后显示出良好的关联。
