Kwak Jeeyoung, Lee You Hyun, Kang Kyung Tae, Kim Yu Cheol
Department of Ophthalmology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
J Clin Med. 2023 Jun 15;12(12):4060. doi: 10.3390/jcm12124060.
Intravitreal bevacizumab (IVB), often injected during cataract surgery, is currently the main treatment for diabetic macular edema. This retrospective study aimed to compare the effectiveness of IVB injections alone and during cataract surgery in patients with diabetic macular edema. We examined 43 eyes in 40 patients who underwent cataract surgery with simultaneous IVB injections 3-12 months after IVB injections alone. Best-corrected visual acuity and central subfield macular thickness (CMT) were measured 1-month post-injection. The CMTs of the same eyes with IVB-only first and combined-treatment procedures later were 384 ± 149 vs. 315 ± 109 μm pretreatment ( = 0.0002), and after 1 month, they were 319 ± 102 vs. 419 ± 183 μm ( < 0.0001). In the IVB-only procedure, 56.1% of eyes had CMT < 300 μm 1 month after the injection compared to 32.5% after the combined treatment. Therefore, on average, when IVB was administered during cataract surgery, CMT increased, whereas after IVB injection alone, it effectively decreased. More prospective trials with large sample sizes are needed to evaluate the effectiveness of IVB injection performed simultaneously with cataract surgery.
玻璃体内注射贝伐单抗（IVB）常用于白内障手术期间，目前是治疗糖尿病性黄斑水肿的主要方法。这项回顾性研究旨在比较单独进行IVB注射与在白内障手术期间进行IVB注射对糖尿病性黄斑水肿患者的疗效。我们检查了40例患者的43只眼睛，这些患者在单独进行IVB注射3至12个月后同时接受了白内障手术及IVB注射。在注射后1个月测量最佳矫正视力和黄斑中心子区域厚度（CMT）。仅先进行IVB注射，之后再进行联合治疗的同一眼睛的CMT，治疗前分别为384±149和315±109μm（P = 0.0002），1个月后分别为319±102和419±183μm（P<0.0001）。在仅进行IVB注射的治疗中，56.1%的眼睛在注射后1个月CMT<300μm，而联合治疗后这一比例为32.5%。因此，平均而言，在白内障手术期间进行IVB注射时，CMT增加，而单独进行IVB注射后，CMT有效降低。需要更多大样本的前瞻性试验来评估与白内障手术同时进行IVB注射的有效性。
