Kumar Lokesh, Dwivedi Monika, Jain Natasha, Shete Pranali, Solanki Subhash, Gupta Rahul, Jain Ashish
Genus Breeding India Pvt Ltd., Pune 411005, Maharashtra, India.
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra 835215, Jharkhand, India.
Life (Basel). 2023 Jun 1;13(6):1313. doi: 10.3390/life13061313.
We do not seem to be the only owner of our body; it houses a large population of microorganisms. Through countless years of coevolution, microbes and hosts have developed complex relationships. In the past few years, the impact of microbial communities on their host has received significant attention. Advanced molecular sequencing techniques have revealed a remarkable diversity of the organ-specific microbiota populations, including in the reproductive tract. Currently, the goal of researchers has shifted to generate and perceive the molecular data of those hidden travelers of our body and harness them for the betterment of human health. Recently, microbial communities of the lower and upper reproductive tract and their correlation with the implication in reproductive health and disease have been extensively studied. Many intrinsic and extrinsic factors influences the female reproductive tract microbiota (FRTM) that directly affects the reproductive health. It is now believed that FRTM dominated by may play an essential role in obstetric health beyond the woman's intimate comfort and well-being. Women with altered microbiota may face numerous health-related issues. Altered microbiota can be manipulated and restored to their original shape to re-establish normal reproductive health. The aim of the present review is to summarize the FRTM functional aspects that influence reproductive health.
我们似乎并非自身身体的唯一主人；它容纳着大量微生物。经过无数年的共同进化，微生物与宿主形成了复杂的关系。在过去几年里，微生物群落对其宿主的影响受到了极大关注。先进的分子测序技术揭示了器官特异性微生物群的显著多样性，包括生殖道中的微生物群。目前，研究人员的目标已转向生成并解读我们体内这些隐藏“旅行者”的分子数据，并利用它们来改善人类健康。最近，下生殖道和上生殖道的微生物群落及其与生殖健康和疾病的关联已得到广泛研究。许多内在和外在因素会影响直接关乎生殖健康的女性生殖道微生物群（FRTM）。现在人们认为，以 为主导的FRTM可能在产科健康中发挥重要作用，而不仅仅关乎女性的私密舒适度和幸福感。微生物群发生改变的女性可能面临众多与健康相关的问题。改变的微生物群可以被调控并恢复到原来的状态，以重新建立正常的生殖健康。本综述的目的是总结影响生殖健康的FRTM功能方面。
