Brusca Ignazio, Barrale Maria, Zarcone Maurizio, Fruscione Santo, Onida Rosa, De Bella Daniele Domenico, Alba Davide, Belluzzo Miriam, Uasuf Carina Gabriela, Cammilleri Gaetano, Costa Antonella, Ferrantelli Vincenzo, Savatteri Alessandra, Cannizzaro Emanuele, Calamusa Giuseppe, Lacca Guido, Maida Carmelo Massimo, Pipitone Salvatore, D'Atria Alida, Palomba Marialetizia, Costantino Claudio, Mattiucci Simonetta, Mazzucco Walter
U.O.C of Clinical Pathology Buccheri La Ferla Hospital FBF, 90123 Palermo, Italy.
U.O.C. of Clinical Epidemiology with Cancer Registry, Azienda Ospedaliera Universitaria Policlinico di Palermo, 90127 Palermo, Italy.
Pathogens. 2023 May 30;12(6):777. doi: 10.3390/pathogens12060777.
The rising popularity of undercooked or raw seafood containing larvae of the parasite has led to issues of public health concern due to allergic manifestations. We conducted an observational study on the use of an innovative allergy diagnostic algorithm in a convenience sample of 53 allergic outpatients recruited in Western Sicily, between April 2021 and March 2022. We included individuals with an anamnesis suggestive of IgE sensitization to reporting clinical manifestation in the last month due to allergic reactions after eating fresh fish, or in subjects at high exposure risk with sea products while abstaining from fish ingestion, excluding those with documented fish sensitization. Outpatients were tested via Skin Prick Test, IgE-specific dosage and Basophil Activation Test (BAT). Twenty-six outpatients were diagnosed with , while 27 with Chronic Urticaria (CU). We found a seven-fold excess risk for (p4) positivity in the allergic outpatients, as compared to the CU ones. BAT showed the best diagnostic accuracy (92.45%) and specificity (100%), while specific IgE to (p1) documented the best sensitivity (92.31%) but a very low specificity (37.04%). In conclusion, our findings may represent a potentially useful contribution to the future development of updated clinical guidelines.
含有该寄生虫幼虫的未煮熟或生海鲜越来越受欢迎，由于过敏表现，已引发公共卫生问题。我们对2021年4月至2022年3月在西西里岛西部招募的53名过敏门诊患者的便利样本使用创新过敏诊断算法进行了一项观察性研究。我们纳入了有提示对[寄生虫名称未给出]IgE致敏的既往史、上个月因食用新鲜鱼类后出现过敏反应而有临床表现的个体，或在避免摄入鱼类的同时有高海产品暴露风险的个体，排除有记录的鱼类致敏个体。门诊患者通过皮肤点刺试验、IgE特异性定量检测和嗜碱性粒细胞活化试验（BAT）进行检测。26名门诊患者被诊断为[疾病名称未给出]，而27名被诊断为慢性荨麻疹（CU）。我们发现，与CU门诊患者相比，[疾病名称未给出]门诊患者中[检测指标未明确]（p4）阳性的风险高出7倍。BAT显示出最佳的诊断准确性（92.45%）和特异性（100%），而针对[物质名称未明确]（p1）的特异性IgE显示出最佳的敏感性（92.31%）但特异性非常低（37.04%）。总之，我们的研究结果可能对未来更新临床指南的制定有潜在的有益贡献。
