Moianos Dimitrios, Prifti Georgia-Myrto, Makri Maria, Zoidis Grigoris
Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Pharmaceuticals (Basel). 2023 Jun 19;16(6):901. doi: 10.3390/ph16060901.
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as and .
金属酶对于多种重要的病毒和寄生虫功能的调节至关重要，包括蛋白质降解、核酸修饰等诸多功能。鉴于传染病对人类健康的影响，抑制金属酶为疾病治疗提供了一种有吸引力的方法。金属螯合剂已被广泛研究作为抗病毒和抗寄生虫药物，从而产生了重要类别的金属依赖性酶抑制剂。本综述介绍了针对对全球公共卫生造成重大负担的病毒和寄生虫的金属酶的最新进展，包括甲型和乙型流感病毒、乙型和丙型肝炎病毒、人类免疫缺陷病毒以及[此处原文缺失部分内容]。
