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柑橘品种果皮中精油的抗炎作用

Anti-Inflammatory Effects of Essential Oils from the Peels of Citrus Cultivars.

作者信息

Yang Jiyoon, Lee Su-Yeon, Jang Soo-Kyeong, Kim Ki-Joong, Park Mi-Jin

机构信息

Forest Industrial Materials Division, Forest Products and Industry Department, National Institute of Forest Science, Seoul 02455, Republic of Korea.

Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.

出版信息

Pharmaceutics. 2023 May 25;15(6):1595. doi: 10.3390/pharmaceutics15061595.

DOI:10.3390/pharmaceutics15061595
PMID:37376044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10301132/
Abstract

Citrus cultivars have remarkable health benefits, but only the anti-inflammatory activities of the major varieties have been studied. This study investigated the anti-inflammatory effects of various citrus cultivars and their active anti-inflammatory components. The essential oils of 21 citrus peels were extracted via hydrodistillation using a Clevenger-type apparatus, and the chemical compositions of the essential oils were analyzed. D-Limonene was the most abundant constituent. To evaluate the anti-inflammatory effects of the citrus cultivars, the gene expression levels of an inflammatory mediator and proinflammatory cytokines were investigated. Among the 21 essential oils, those extracted from and exhibited superior anti-inflammatory activities, being able to inhibit the expression of the inflammatory mediators and proinflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 cells. The essential oils of and were distinguished into seven distinct constituents, α-pinene, myrcene, D-limonene, β-ocimene, linalool, linalool oxide, and α-terpineol, compared with other essential oils. The anti-inflammatory activities of the seven single compounds significantly inhibited the levels of inflammation-related factors. In particular, α-terpineol exhibited a superior anti-inflammatory effect. This study showed that the essential oils from and exhibit high anti-inflammatory activity. In addition, α-terpineol is an active anti-inflammatory compound that contributes to inflammatory responses.

摘要

柑橘品种具有显著的健康益处，但仅对主要品种的抗炎活性进行了研究。本研究调查了各种柑橘品种及其活性抗炎成分的抗炎作用。使用克莱文杰型装置通过水蒸馏法提取了21种柑橘皮的精油，并对精油的化学成分进行了分析。D-柠檬烯是含量最丰富的成分。为了评估柑橘品种的抗炎作用，研究了炎症介质和促炎细胞因子的基因表达水平。在这21种精油中，从[具体品种1]和[具体品种2]中提取的精油表现出卓越的抗炎活性，能够抑制脂多糖刺激的RAW 264.7细胞中炎症介质和促炎细胞因子的表达。与其他精油相比，[具体品种1]和[具体品种2]的精油可分为七种不同成分，即α-蒎烯、月桂烯、D-柠檬烯、β-罗勒烯、芳樟醇、氧化芳樟醇和α-松油醇。这七种单一化合物的抗炎活性显著抑制了炎症相关因子的水平。特别是，α-松油醇表现出卓越的抗炎效果。本研究表明，来自[具体品种1]和[具体品种2]的精油具有高抗炎活性。此外，α-松油醇是一种有助于炎症反应的活性抗炎化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/1b1a27969b3c/pharmaceutics-15-01595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/5b6f95b44cec/pharmaceutics-15-01595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/c9d7a18e92da/pharmaceutics-15-01595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/8d6b18868996/pharmaceutics-15-01595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/751ba620679e/pharmaceutics-15-01595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/e80fa9aa05f3/pharmaceutics-15-01595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/1b1a27969b3c/pharmaceutics-15-01595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/5b6f95b44cec/pharmaceutics-15-01595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/c9d7a18e92da/pharmaceutics-15-01595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/8d6b18868996/pharmaceutics-15-01595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/751ba620679e/pharmaceutics-15-01595-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/e80fa9aa05f3/pharmaceutics-15-01595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/10301132/1b1a27969b3c/pharmaceutics-15-01595-g006.jpg

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