Lestido-Cardama Antía, Barbosa-Pereira Letricia, Sendón Raquel, Paseiro Losada Perfecto, Rodríguez Bernaldo de Quirós Ana
Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Instituto de Materiales (iMATUS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Polymers (Basel). 2023 Jun 12;15(12):2656. doi: 10.3390/polym15122656.
Alkyl diethanolamines are a group of compounds commonly used as antistatic agents in plastic food packaging materials. These additives and their possible impurities have the ability to transfer into the food; hence, the consumer may be exposed to these chemicals. Recently, scientific evidence of unknown adverse effects associated with these compounds was reported. N,N-bis(2-hydroxyethyl)alkyl (C8-C18) amines as well as other related compounds and their possible impurities were analyzed in different plastic packaging materials and coffee capsules using target and non-target LC-MS methods. N,N-bis(2-hydroxyethyl)alkyl amines, precisely, C12, C13, C14, C15, C16, C17 and C18, 2-(octadecylamino)ethanol and octadecylamine, among others, were identified in most of the analyzed samples. It should be emphasized that the latter compounds are not listed in the European Regulation 10/2011 and 2-(octadecylamino)ethanol was classified as high toxicity according to Cramer rules. Migration tests were carried out in foods and in the food simulants Tenax and 20% ethanol (/). The results showed that stearyldiethanolamine migrated into the tomato, salty biscuits, salad and Tenax. Lastly, as a crucial step in the risk assessment process, the dietary exposure to stearyldiethanolamine transferred from the food packaging into the food was determined. The estimated values ranged from 0.0005 to 0.0026 µg/kg bw/day.
烷基二乙醇胺是一类常用于塑料食品包装材料中的抗静电剂。这些添加剂及其可能含有的杂质能够迁移到食品中，因此消费者可能会接触到这些化学物质。最近，有报道称这些化合物存在未知的不良影响的科学证据。采用靶向和非靶向液相色谱-质谱法对不同塑料包装材料和咖啡胶囊中的N,N-双(2-羟乙基)烷基(C8-C18)胺以及其他相关化合物及其可能含有的杂质进行了分析。在大多数分析样品中鉴定出了N,N-双(2-羟乙基)烷基胺，具体为C12、C13、C14、C15、C16、C17和C18，还有2-(十八烷基氨基)乙醇和十八烷基胺等。需要强调的是，后几种化合物未列入欧盟法规10/2011中，且根据克莱默规则，2-(十八烷基氨基)乙醇被归类为高毒性物质。在食品以及食品模拟物Tenax和20%乙醇中进行了迁移试验。结果表明，硬脂酰二乙醇胺迁移到了番茄、咸味饼干、沙拉和Tenax中。最后，作为风险评估过程中的关键一步，测定了从食品包装转移到食品中的硬脂酰二乙醇胺的膳食暴露量。估计值范围为0.0005至0.0026 µg/kg体重/天。
