采用 UPLC-Q-TOF-MS 鉴定婴儿奶瓶中的非挥发性迁移物。
Identification of non-volatile migrants from baby bottles by UPLC-Q-TOF-MS.
机构信息
Department of Food Science, School of Food Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Department of Analytical Chemistry, GUIA Group, Aragon Institute of Engineering Research I3A, University of Zaragoza, Zaragoza, Spain.
出版信息
Food Res Int. 2019 Sep;123:529-537. doi: 10.1016/j.foodres.2019.05.012. Epub 2019 May 10.
Baby bottles made of polypropylene, Tritan® and silicone were evaluated regarding the migration of non-volatile compounds using UPLC-QTOF-MS. Twenty-seven compounds were identified. In all polypropylene samples the migration of 2.2'-(tridecylimino)bis-ethanol and derivatives thereof were detected in concentrations below the specific migration limit (1.2 mg.kg). Furthermore, clarifying agents and glycerol derivatives were detected. Tritan baby bottle showed the migration of one slip additive. On the other hand, twenty compounds were detected in silicone baby bottles. Most of them were unknown compounds derived from acrylates. Once the migrants were identified, the risk assessment was carried out using the Threshold of Toxicological Concern (TTC) approach. The risk assessment of migrants coming from silicone samples showed levels above the threshold recommended as safe for babies.
采用 UPLC-QTOF-MS 对聚丙稀、Tritan® 和硅树脂婴儿奶瓶中非挥发性化合物的迁移情况进行了评估。鉴定出 27 种化合物。在所有聚丙稀样本中，均检测到迁移量低于特定迁移限量（1.2 mg/kg）的 2.2'-(十三烷基亚氨基）双-乙醇及其衍生物。此外，还检测到澄清剂和甘油衍生物。Tritan 婴儿奶瓶中迁移出一种滑爽剂。另一方面，在硅树脂婴儿奶瓶中检测到 20 种化合物。其中大部分是源自丙烯酸酯的未知化合物。在鉴定出迁移物后，采用毒理学关注阈值（TTC）方法进行了风险评估。硅树脂样品中迁移物的风险评估显示，其水平超过了推荐给婴儿使用的安全阈值。
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