Fernández Katherina, Llanquileo Aylen, Bustos Monserrat, Aedo Valentina, Ruiz Isleidy, Carrasco Sebastián, Tapia Mauricio, Pereira Miguel, Meléndrez Manuel F, Aguayo Claudio, Atanase Leonard I
Laboratorio de Biomateriales, Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Concepción, Concepción 4070386, Chile.
Laboratorio de Productos Forestales, Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Concepción, Concepción 4070386, Chile.
Polymers (Basel). 2023 Jun 20;15(12):2752. doi: 10.3390/polym15122752.
In this study, a conductive composite material, based on graphene oxide (GO), nanocellulose (CNF), and tannins (TA) from pine bark, reduced using polydopamine (PDA), was developed for wound dressing. The amount of CNF and TA was varied in the composite material, and a complete characterization including SEM, FTIR, XRD, XPS, and TGA was performed. Additionally, the conductivity, mechanical properties, cytotoxicity, and in vitro wound healing of the materials were evaluated. A successful physical interaction between CNF, TA, and GO was achieved. Increasing CNF amount in the composite reduced the thermal properties, surface charge, and conductivity, but its strength, cytotoxicity, and wound healing performance were improved. The TA incorporation slightly reduced the cell viability and migration, which may be associated with the doses used and the extract's chemical composition. However, the in-vitro-obtained results demonstrated that these composite materials can be suitable for wound healing.
在本研究中，开发了一种基于氧化石墨烯（GO）、纳米纤维素（CNF）和来自松树皮的单宁（TA）的导电复合材料，该材料使用聚多巴胺（PDA）进行还原，用于伤口敷料。复合材料中CNF和TA的含量有所变化，并对其进行了包括扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、X射线光电子能谱（XPS）和热重分析（TGA）在内的全面表征。此外，还评估了材料的导电性、力学性能、细胞毒性和体外伤口愈合能力。CNF、TA和GO之间成功实现了物理相互作用。复合材料中CNF含量的增加降低了热性能、表面电荷和导电性，但其强度、细胞毒性和伤口愈合性能得到了改善。TA的加入略微降低了细胞活力和迁移能力，这可能与所用剂量和提取物的化学成分有关。然而，体外获得的结果表明，这些复合材料适用于伤口愈合。
