Mohammedsaeed Walaa, Alsehli Fahad, Alfarsi Lutfi, Bakhsh Ameen, Alzahrani Mansour, Almarwani Maram, Alharbi Yousef
Diabetes and Endocrinology, Clinical Biochemistry, Taibah University, Madinah, SAU.
Pathology, King Salman Medical City, Madinah, SAU.
Cureus. 2023 May 23;15(5):e39408. doi: 10.7759/cureus.39408. eCollection 2023 May.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected people of all ages, but limited data are available on children with mild and severe coronavirus disease 2019 (COVID-19).
Clinical characteristics, inflammation, and other biochemical biomarkers have been described, but information is scarce in asymptomatic and mild cases. Laboratory investigations were performed with pediatric patients (n=70) for liver function and kidney function, along with C-reactive protein (CRP).
Mild clinical characteristics and symptoms were observed in pediatric patients. Even in moderate cases of COVID-19, elevated levels of biomarkers indicate altered liver and kidney function in children. The levels of liver enzymes, bilirubin, creatinine, and CRP varied significantly between the three classes, particularly between asymptomatic and moderate cases. Liver enzymes, bilirubin, and creatinine levels in moderate COVID-19 pediatric cases were twice as elevated as in asymptomatic cases. Liver enzymes and CRP levels were moderately elevated.
Monitoring blood biomarkers consistently can assist in the accurate identification of infection in young patients as well as in the prevention of its spread and the administration of appropriate treatment.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已感染了所有年龄段的人群，但关于儿童轻度和重度冠状病毒病2019（COVID-19）的数据有限。
已对临床特征、炎症及其他生化生物标志物进行了描述，但无症状和轻症病例的相关信息较少。对儿科患者（n = 70）进行了肝功能、肾功能以及C反应蛋白（CRP）的实验室检查。
儿科患者表现出轻度临床特征和症状。即使在中度COVID-19病例中，生物标志物水平升高也表明儿童的肝肾功能发生了改变。三类患者之间肝酶、胆红素、肌酐和CRP水平差异显著，尤其是无症状和中度病例之间。中度COVID-19儿科病例的肝酶、胆红素和肌酐水平是无症状病例的两倍。肝酶和CRP水平中度升高。
持续监测血液生物标志物有助于准确识别年轻患者的感染情况，以及预防感染传播和实施适当治疗。
