Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
Université Paris Cité, T3S, Inserm UMR S-1124, 75006 Paris, France.
Environ Int. 2023 Aug;178:108056. doi: 10.1016/j.envint.2023.108056. Epub 2023 Jun 22.
Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents.
This study included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (p,p'-Dichlorodiphenyldichloroethylene [p,p'-DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), percentage of fat mass, and blood pressure (mmHg) were measured at around 12 years of age. Single-exposure associations were studied using linear or logistic regressions, and the POP mixture effect was evaluated using quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and performed for boys and girls together and separately.
Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These mixture effects were also statistically significant using BKMR. These associations were driven mainly by exposure to HCB and, to a lesser extent, to β-HCH. In addition, the single-exposure models showed an association between β-HCH and p,p'-DDE and higher systolic blood pressure, especially in girls (p,p'-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found for PCBs.
This study suggests that prenatal exposure to POPs, particularly organochlorine pesticides, remains associated with unfavorable cardiometabolic health up to the age of 12.
多项研究报告称，产前接触某些持久性有机污染物 (POPs) 与儿童期肥胖有关。很少有研究评估这种发现是否持续到青春期，也很少有研究考虑将 POPs 作为混合物进行暴露。本研究旨在评估产前暴露于多种 POPs 与青少年前体脂肪标志物和血压之间的关联。
本研究纳入了来自法国 PELAGIE 队列和西班牙 INMA 队列的 1667 对母婴对子。检测了母体或脐带血清中的三种多氯联苯 (PCB138、153 和 180，作为多氯联苯的总和) 和三种有机氯农药 (p,p'-二氯二苯二氯乙烯 [p,p'-DDE]、β-六氯环己烷 [β-HCH] 和六氯苯 [HCB])。在大约 12 岁时测量体重指数 z 分数 (zBMI)、腹部肥胖 (腰高比>0.5)、体脂百分比和血压 (mmHg)。使用线性或逻辑回归研究单一暴露的相关性，并使用分位数 G 计算 (qgComp) 和贝叶斯核机器回归 (BKMR) 评估 POP 混合物的效果。所有模型均根据潜在混杂因素进行调整，并同时和分别在男孩和女孩中进行。
产前接触 POP 混合物与 zBMI 升高相关（qgComp 的 beta [95%CI] = 0.15 [0.07; 0.24]）和体脂百分比升高相关（0.83 [0.31; 1.35]），且无性别特异性关联。使用 BKMR 也得到了这些混合物效应的统计学显著结果。这些关联主要归因于 HCB 的暴露，其次是β-HCH。此外，单一暴露模型显示β-HCH 和 p,p'-DDE 与收缩压升高之间存在关联，尤其是在女孩中（p,p'-DDE 女孩= 1.00 [0.15; 1.86]）。多氯联苯没有显著相关性。
本研究表明，产前接触 POPs，尤其是有机氯农药，与 12 岁时不良的心脏代谢健康状况有关。
