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印度贫血和神经管缺陷(NTDs)悄无声息的悲惨现实。

The silent tragic reality of anaemia, and neural-tube defects (NTDs) in India.

作者信息

Antony Aśok C, Vora Ravindra M, Karmarkar Santosh J

机构信息

Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Department of Paediatric Surgery, Paediatric Surgery Centre & Post-Graduate Institute, Implementing The Lancet Commission on Global Surgery in India, Sangli, Maharashtra, India.

出版信息

Lancet Reg Health Southeast Asia. 2022 Sep 17;6:100071. doi: 10.1016/j.lansea.2022.100071. eCollection 2022 Nov.

DOI:10.1016/j.lansea.2022.100071
PMID:37383344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10305893/
Abstract

arising from nutritional iron-, folate-, and vitamin-B-deficiencies is exceedingly common in India and has profound negative impacts on anaemia, on pregnancy, and on embryonic-foetal neurodevelopment which predisposes to NTDs and psychological-psychiatric manifestations in childhood. Whereas younger-to-middle-aged Indians fail to perform at maximum potential, the elderly are at risk for calamitous neurologic events. However, these micronutrient-deficiencies are eminently correctable through food-fortification. Therefore, the Indian Government can no longer afford the luxury of inaction by either denying or downplaying the gravity of this problem. What is critically needed from India's leaders is an urgent, clear-eyed reappraisal and act of anagnorisis-(an often startling self-recognition and discovery of a profoundly serious error and tragic flaw)-in failing to confront this problem for decades. Only when closely followed by a metanoia-(a transformative change of heart that triggers remedial action)-can they help India avoid a catastrophic tryst with destiny.

摘要

由营养性缺铁、缺叶酸和维生素B引起的情况在印度极为常见,对贫血、妊娠以及胚胎-胎儿神经发育产生深远的负面影响,而胚胎-胎儿神经发育易引发神经管缺陷以及儿童期的心理-精神症状。当中青年印度人无法发挥出最大潜能时,老年人则面临灾难性神经事件的风险。然而,这些微量营养素缺乏症可通过食品强化得到显著改善。因此,印度政府再也不能对这一问题的严重性视而不见或轻描淡写,从而无所作为了。印度领导人亟需进行紧急、清醒的重新评估,并对几十年来未能正视这一问题进行幡然醒悟(通常是令人震惊的自我认知以及发现严重错误和悲剧性缺陷)。只有紧接着进行痛悔(引发补救行动的内心转变),他们才能帮助印度避免与命运的灾难性邂逅。

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BMJ Nutr Prev Health. 2021 Jun 23;4(1):293-306. doi: 10.1136/bmjnph-2020-000209. eCollection 2021.
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Anemia and Vitamin B-12 and Folate Status in Women of Reproductive Age in Southern India: Estimating Population-Based Risk of Neural Tube Defects.
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