Bhargava Seema, Srivastava Lalit Mohan, Manocha Anjali, Kankra Mamta, Rawat Sonia
Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.
Executive Health Check-Up, Sir Ganga Ram Hospital, New Delhi, India.
Indian J Clin Biochem. 2022 Apr;37(2):149-158. doi: 10.1007/s12291-021-00966-1. Epub 2021 Mar 9.
Prevalence of anemia in India is almost 40% with no significant change since 1998-99, whereas globally this prevalence has been reduced to < 15%. This could be because our national nutritional programs (mainly National Nutritional Anemia Control Program-NNACP) focus on supplementation with iron and folate but not with vitamin B12. Some Indian studies, including our study (2012), indicated high prevalence of B12 deficiency in North Indian urban population. Hence, we conducted a retrospective analysis of 3 years' data (2012-2014 including 48,317 subjects) and compared it with last year's retrospective data (April 2019-March 2020 including 4775 subjects) to ascertain prevalence of deficiencies of these micronutrient with special reference to patients of anemia, and improvement therein over the subsequent 5-year period. Our results indicate that amongst our subjects with anemia, iron deficiency has reduced from 66.73% (2012-2014) to 56.86% (2019), but prevalence of vitamin B12 deficiency is still the same (36.54% in 2012-2014; 37.04% in 2019). Folate deficiency was similar in both sets of data (2.95% in 2012-2014 and 2.55% in 2019). Thus, NNACP has reduced prevalence of iron deficiency by ~ 10%points and folate deficiency marginally; B12 deficiency has not been addressed. It would, therefore, follow that we need to add to our current national programs to effectively deal with these deficiencies. Food fortification (with iron, folate and B12) seems the most likely means to add value to the existing programs. In addition, food diversification needs to be included in regular school curriculum to bring about community awareness and change in food habits.
印度贫血症的患病率近40%,自1998 - 1999年以来没有显著变化,而全球这一患病率已降至<15%。这可能是因为我们的国家营养计划(主要是国家营养性贫血控制计划 - NNACP)侧重于补充铁和叶酸,而不包括维生素B12。包括我们的研究(2012年)在内的一些印度研究表明,印度北部城市人口中维生素B12缺乏症的患病率很高。因此,我们对三年的数据(2012 - 2014年,包括48317名受试者)进行了回顾性分析,并将其与去年的回顾性数据(2019年4月 - 2020年3月,包括4775名受试者)进行比较,以确定这些微量营养素缺乏症的患病率,特别是针对贫血患者,并了解在随后的5年中患病率的改善情况。我们的结果表明,在我们的贫血受试者中,缺铁率从2012 - 2014年的66.73%降至2019年的56.86%,但维生素B12缺乏症的患病率仍然相同(2012 - 2014年为36.54%;2019年为37.04%)。两组数据中的叶酸缺乏率相似(2012 - 2014年为2.95%,2019年为2.55%)。因此,NNACP已将缺铁率降低了约10个百分点,叶酸缺乏率略有降低;但维生素B12缺乏症问题尚未得到解决。因此,我们需要在当前的国家计划中增加内容,以有效应对这些缺乏症。食品强化(添加铁、叶酸和B12)似乎是为现有计划增加价值的最有可能的手段。此外,需要将食物多样化纳入正规学校课程,以提高社区意识并改变饮食习惯。