埃塞俄比亚提格雷州梅凯勒市非营利性私立诊所就诊患者中的患病率、抗生素耐药性及相关因素

Prevalence, Antibiotic Resistance and Associated Factors of Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia.

作者信息

Kahsay Atsebaha Gebrekidan, Mezgebo Tadele Araya, Gebrekidan Gebregziabher Berihu, Desta Birhane Lemlem, Mihretu Hagos Gidey, Dejene Tsehaye Asmelash

机构信息

Department of Medical Microbiology and Immunology, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Tigrai, Ethiopia.

Department of Health Systems, School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Tigrai, Ethiopia.

出版信息

Infect Drug Resist. 2023 Jun 23;16:4065-4072. doi: 10.2147/IDR.S416344. eCollection 2023.

DOI:10.2147/IDR.S416344

PMID:37383604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10295600/

Abstract

BACKGROUND

Globally, is the second most common cause of bacterial sexually transmitted diseases. The prominent predicament of this bacterium is its complications, non-susceptibility for many drugs, and aggravated transmission of other sexually transmitted infections. There is limited information about the prevalence, antibiotic resistance, and risk factors of in Tigrai, Ethiopia. Therefore, we aimed to determine the prevalence, antibiotic resistance, and risk factors of among patients attending non-profitable private clinics in Mekelle, Tigrai, Ethiopia.

METHODS

A cross-sectional study among 229 patients was conducted from February to June 2018. The socio-demographic data and associated factors were gathered using structured questionnaire, and swabs were taken from urethra and cervix of males and females, respectively. Specimens were inoculated on standard bacteriological culture media and antibiotic susceptibility testing was performed using Kirby-Bauer disc diffusion technique following the Clinical and Laboratory Standard Institute. Data were analyzed using Statistical Package for Social Sciences Version 21. The level of significance at p-value <0.05 was considered statistically significant.

RESULTS

The overall prevalence of was 23 (10.04%). High prevalence rates of were observed in females, urban residents and married ones. had shown statistically significant association with HIV positive, previous history of STIs, shisha users, Khat () users, condom non-users and having more than two sexual partners. All isolates showed resistance to penicillin followed by tetracycline 16 (69.6%) and ciprofloxacin 8 (34.8%). Four isolates (7.4%) exhibited resistance to azithromycin with no resistance to ceftriaxone. Twelve (52.2%) isolates showed multidrug resistance (MDR).

CONCLUSIONS

The prevalence of and drug resistance, including multidrug resistance, was high in the study. Multiple factors were associated with the acquisition of . Therefore, behavioral change and communication should be strengthened.

摘要

背景

在全球范围内，[该细菌名称未给出]是细菌性性传播疾病的第二大常见病因。这种细菌的突出困境在于其并发症、对多种药物不敏感以及加剧其他性传播感染的传播。在埃塞俄比亚提格雷，关于[该细菌名称未给出]的流行情况、抗生素耐药性和危险因素的信息有限。因此，我们旨在确定埃塞俄比亚提格雷梅凯勒非盈利私立诊所就诊患者中[该细菌名称未给出]的流行情况、抗生素耐药性和危险因素。

方法

2018年2月至6月对229名患者进行了一项横断面研究。使用结构化问卷收集社会人口学数据和相关因素，并分别从男性和女性的尿道和宫颈采集拭子。将标本接种在标准细菌学培养基上，并按照临床和实验室标准研究所的方法使用 Kirby - Bauer 纸片扩散技术进行抗生素敏感性测试。使用社会科学统计软件包第21版对数据进行分析。p值<0.05的显著性水平被认为具有统计学意义。

结果

[该细菌名称未给出]的总体流行率为23例（10.04%）。在女性、城市居民和已婚者中观察到较高的[该细菌名称未给出]流行率。[该细菌名称未给出]与艾滋病毒阳性、既往性传播感染史、水烟使用者、恰特草（[恰特草英文未给出]）使用者、不使用避孕套者以及有两个以上性伴侣者之间存在统计学显著关联。所有分离株均对青霉素耐药，其次是对四环素耐药的有16株（69.6%），对环丙沙星耐药的有8株（34.8%）。4株分离株（7.4%）对阿奇霉素耐药，对头孢曲松无耐药。12株（52.2%）分离株表现出多重耐药（MDR）。