Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Department of Ophthalmology, Tianjin Beichen Traditional Chinese Medicine Hospital, Tianjin, China.
Ophthalmic Epidemiol. 2024 Apr;31(2):178-187. doi: 10.1080/09286586.2023.2225582. Epub 2023 Jun 30.
The urbanization of suburbs has a significant impact on ocular health, however, the effect of this phenomenon on the epidemiology of eye diseases in the sub-urbanization region of China remains unclear. In this context, the population-based Beichen Eye Study (BCES) was conducted in the Beichen District of Tianjin, China. This article aims to summarize the background, design scheme and operation process of the study. The Chinese Clinical Trial Registry number was ChiCTR2000032280.
In total, 8218 participants were randomly selected by a multi-stage sampling method. After their qualification was confirmed, participants were mainly invited to a centralized clinic via telephone interviews after promotion of the study in the community. Examinations included a standardized interview, anthropometric assessment, autorefraction, ocular biometry, visual acuity, anterior and posterior segment examinations, dry eye disease (DED), intra-ocular pressure, visual field testing, gonioscopy, and imaging of anterior segment, posterior segment, fundus, and optic disc. A peripheral venous blood sample was also collected for biochemical testing. For observational purposes, a community-based type II diabetes mellitus management mode was created and assessed for its effect in preventing the progression of diabetic retinopathy (DR).
Of the 8,218 residents, 7,271 were eligible for inclusion, and 5,840 (80.32%) subjects were enrolled in the BCES. Most of the participants were female (64.38%) with a median age of 63 years, and 98.23% representing Han Chinese descent. Conclusions: This study provides insights into the epidemiological characteristics of major ocular diseases and their moderators in a suburbanized region of China.
郊区的城市化对眼部健康有重大影响，但这一现象对中国城郊化地区眼病流行病学的影响尚不清楚。在此背景下，在中国天津市北辰区开展了一项基于人群的北辰眼研究（BCES）。本文旨在总结该研究的背景、设计方案和实施过程。中国临床试验注册中心的注册号为 ChiCTR2000032280。
采用多阶段抽样方法，随机抽取 8218 名参与者。在确认其资格后，主要通过电话访谈邀请符合条件的参与者到集中诊所。检查包括标准化访谈、人体测量评估、自动验光、眼生物测量、视力、眼前段和后段检查、干眼症（DED）、眼压、视野检查、房角镜检查、眼前段、后段、眼底和视盘成像。还采集外周静脉血样进行生化检测。为了观察目的，创建了一种基于社区的 2 型糖尿病管理模式，并评估其在预防糖尿病视网膜病变（DR）进展方面的效果。
在 8218 名居民中，有 7271 名符合纳入标准，其中 5840 名（80.32%）参与者被纳入 BCES。大多数参与者为女性（64.38%），中位年龄为 63 岁，98.23%为汉族。结论：本研究提供了中国城郊化地区主要眼部疾病及其调节剂的流行病学特征的见解。
