Sellera Fábio P, Fuentes-Castillo Danny, Fuga Bruna, Goldberg Daphne W, Kolesnikovas Cristiane K M, Lincopan Nilton
Department of Internal Medicine, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil.
One Health. 2023 Jun 22;17:100590. doi: 10.1016/j.onehlt.2023.100590. eCollection 2023 Dec.
Olive ridley () turtles migrate across tropical regions of the Atlantic, Pacific, and Indian Oceans. Worryingly, olive ridley populations have been declining substantially and is now considered a threatened species. In this regard, habitat degradation, anthropogenic pollution, and infectious diseases have been the most notorious threats for this species. We isolated a metallo-β-lactamase (NDM-1)-producing from the blood sample of an infected migratory olive ridley turtle found stranded sick in the coast of Brazil. Genomic analysis of confirmed a novel sequence type (ST), named ST264, and a wide resistome to broad-spectrum antibiotics. The production of NDM-1 by the strain contributed to treatment failure and death of the animal. Phylogenomic relationship with environmental and human strains from African, European and Asian countries confirmed that critical priority clones of are spreading beyond hospital settings, representing an emerging ecological threat to marine ecosystems.
蠵龟在大西洋、太平洋和印度洋的热带地区迁徙。令人担忧的是，蠵龟的数量一直在大幅下降，现在被认为是濒危物种。在这方面，栖息地退化、人为污染和传染病一直是该物种最臭名昭著的威胁。我们从一只在巴西海岸搁浅生病的受感染迁徙蠵龟的血液样本中分离出一株产金属β-内酰胺酶（NDM-1）的[细菌名称未给出]。对[细菌名称未给出]的基因组分析证实了一种新的序列类型（ST），命名为ST264，以及对广谱抗生素的广泛耐药组。该菌株产生的NDM-1导致了动物的治疗失败和死亡。与来自非洲、欧洲和亚洲国家的环境菌株和人类菌株的系统发育关系证实，[细菌名称未给出]的关键优先克隆正在医院环境之外传播，对海洋生态系统构成新出现的生态威胁。
