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高毒力和耐碳青霉烯在不同进化模式下的流行情况。

Prevalence of hypervirulent and carbapenem-resistant under divergent evolutionary patterns.

机构信息

Department of Clinical Laboratory, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

School of Pharmacy, Fudan University, Shanghai, People's Republic of China.

出版信息

Emerg Microbes Infect. 2022 Dec;11(1):1936-1949. doi: 10.1080/22221751.2022.2103454.

DOI:10.1080/22221751.2022.2103454
PMID:35844192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9359173/
Abstract

K1/K2 hvKP strains acquire carbapenem-resistance plasmids, known as CR-hvKp, and carbapenem-resistant (CRKP) strains obtain virulence plasmids, recognized as hv-CRKP. The two different evolution patterns of hypervirulent combined carbapenem-resistant may lead to their different prevalence in hospitals. Our study aimed to investigate the prevalence of hv-CRKP and CR-hvKp strains and to analyze factors influencing their evolution and prevalence. We collected 890 genomes from GenBank and 530 clinical isolates from nine hospitals. Our study found that hv-CRKP strains were more prevalent than CR-hvKp strains and both were dominated by gene. The -carrying plasmids could mobilize non-conjugative virulence plasmids from hvKp strains to CRKP strains. The conserved of virulence plasmids and the widespread of conjugative helper plasmids were potential factors for the mobilization of non-conjugative virulence plasmids. HvKp strains with KPC plasmid could hardly simultaneously exhibit hypervirulence and carbapenem resistance as CRKP strains with virulence plasmid, and we found that mutation reduced capsular synthesis and increased carbapenem resistance of the CR-hvKp strain. In summary, this study revealed that hv-CRKP strains were more suitable for survival in hospital settings than CR-hvKp strains and the widespread conjugative KPC-producing plasmids contributed to the emergence and prevalence of hv-CRKP strains.

摘要

K1/K2 hvKP 菌株获得碳青霉烯类耐药质粒，称为 CR-hvKp，而碳青霉烯类耐药（CRKP）菌株获得毒力质粒，称为 hv-CRKP。超毒力结合碳青霉烯类耐药的两种不同进化模式可能导致它们在医院中的流行程度不同。本研究旨在调查 hv-CRKP 和 CR-hvKp 菌株的流行情况，并分析影响其进化和流行的因素。我们从 GenBank 收集了 890 个基因组和 9 家医院的 530 个临床分离株。我们的研究发现，hv-CRKP 菌株比 CR-hvKp 菌株更为普遍，且两者均以 基因为主导。携带 -基因的质粒可以将非接合性毒力质粒从 hvKp 菌株转移到 CRKP 菌株。毒力质粒的保守性和广泛存在的接合辅助质粒是非接合性毒力质粒转移的潜在因素。带有 KPC 质粒的 hvKp 菌株几乎不可能同时表现出超毒力和 CRKP 菌株的碳青霉烯类耐药性，我们发现 突变降低了荚膜合成并增加了 CR-hvKp 菌株的碳青霉烯类耐药性。总之，本研究表明 hv-CRKP 菌株比 CR-hvKp 菌株更适合在医院环境中生存，广泛存在的接合性 KPC 产生质粒有助于 hv-CRKP 菌株的出现和流行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/8f816be9b00b/TEMI_A_2103454_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/80d3e23052d2/TEMI_A_2103454_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/21bc27914fba/TEMI_A_2103454_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/4d7d8593920a/TEMI_A_2103454_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/af26a6ed22db/TEMI_A_2103454_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/bc2a02cf98eb/TEMI_A_2103454_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/8f816be9b00b/TEMI_A_2103454_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/80d3e23052d2/TEMI_A_2103454_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/21bc27914fba/TEMI_A_2103454_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/4d7d8593920a/TEMI_A_2103454_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/af26a6ed22db/TEMI_A_2103454_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/bc2a02cf98eb/TEMI_A_2103454_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa3d/9359173/8f816be9b00b/TEMI_A_2103454_F0006_OC.jpg

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