胃泌素和促胰液素对胃癌和结肠癌的调节作用。
Regulatory effects of gastrin and secretin on carcinomas of the stomach and colon.
作者信息
Tanaka J, Yamaguchi T, Takahashi T, Ogata N, Bando K, Koyama K
出版信息
Tohoku J Exp Med. 1986 Apr;148(4):459-60. doi: 10.1620/tjem.148.459.
PMID:3738909
Abstract
Gastrin (10 micrograms/ml) enhanced 14C-leucine uptake in cultured tissue of stomach and colon carcinomas and content of 14C-labelled protein in the medium was increased. One of 2 stomach and one of 3 colon carcinomas transplanted into nude mice were enhanced in growth by pentagastrin injected in a dose of 250 micrograms/kg every day. On the other hand, secretin (100 U/kg) inhibited the trophic action of pentagastrin.
摘要
胃泌素（10微克/毫升）可增强培养的胃癌和结肠癌组织对14C-亮氨酸的摄取，并且培养基中14C标记蛋白的含量增加。移植到裸鼠体内的2例胃癌中的1例以及3例结肠癌中的1例，通过每天注射剂量为250微克/千克的五肽胃泌素，生长得到增强。另一方面，促胰液素（100单位/千克）可抑制五肽胃泌素的促生长作用。
Zotero 插件