乙二醇单甲醚的一种可能代谢产物2-甲氧基乙醛对大鼠的睾丸毒性。

Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat.

作者信息

Foster P M, Blackburn D M, Moore R B, Lloyd S C

出版信息

Toxicol Lett. 1986 Jul-Aug;32(1-2):73-80. doi: 10.1016/0378-4274(86)90051-2.

Abstract

2-Methoxyacetaldehyde (MALD) was shown to produce specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures as evidenced by morphological changes to these cells, an increase in germ-cell detachment and leakage of the pachytene spermatocyte marker enzyme lactate dehydrogenase-X. These effects occurred at concentrations where the known testicular toxicant, 2-methoxyacetic acid (MAA) was without effect (0.2 and 0.5 mM). In vivo, MALD also produced the characteristic testicular lesion reported previously for MAA and its parent compound ethylene glycol monomethyl ether (EGME). It is likely that MALD plays an important role in EGME-induced testicular toxicity.

摘要

2-甲氧基乙醛（MALD）在混合睾丸细胞培养物中对粗线期精母细胞产生特异性细胞毒性，这些细胞的形态变化、生殖细胞脱离增加以及粗线期精母细胞标记酶乳酸脱氢酶-X的泄漏都证明了这一点。这些效应发生在已知的睾丸毒物2-甲氧基乙酸（MAA）无作用的浓度（0.2和0.5 mM）下。在体内，MALD还产生了先前报道的MAA及其母体化合物乙二醇单甲醚（EGME）所具有的特征性睾丸损伤。MALD可能在EGME诱导的睾丸毒性中起重要作用。