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采用快速简便的方法测定尿中烷氧基乙酸,用于对接触乙二醇醚及其乙酸酯的工人进行生物监测。

Determination of urinary alkoxyacetic acids by a rapid and simple method for biological monitoring of workers exposed to glycol ethers and their acetates.

作者信息

Sakai T, Araki T, Masuyama Y

机构信息

Center of Occupational Medicine, Tokyo Labor Accident Hospital, Japan.

出版信息

Int Arch Occup Environ Health. 1993;64(7):495-8. doi: 10.1007/BF00381097.

DOI:10.1007/BF00381097
PMID:8482589
Abstract

In control subjects and workers exposed to glycol ethers and their acetates, we determined the urinary metabolites (three alkoxyacetic acids) by a simple and rapid method. Levels of urinary metabolites were significantly higher in the solvent workers than in the nonexposed subjects. The exposure levels measured by personal monitoring of breathing zone air were far below the threshold limit value. The present results indicate that determination of urinary alkoxyacetic acids by the practical method used here is useful for evaluating excessive exposure to solvents.

摘要

在对照组以及接触乙二醇醚及其醋酸酯的工人中,我们采用一种简单快速的方法测定了尿代谢物(三种烷氧基乙酸)。溶剂接触工人的尿代谢物水平显著高于未接触者。通过对呼吸带空气进行个人监测测得的接触水平远低于阈限值。本研究结果表明,采用此处所用的实用方法测定尿烷氧基乙酸,对于评估溶剂过度接触情况很有用。

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引用本文的文献

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本文引用的文献

1
Comparative short-term inhalation toxicity of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in rats and mouse.乙二醇单甲醚和丙二醇单甲醚对大鼠和小鼠的短期吸入毒性比较
Toxicol Appl Pharmacol. 1981 Dec;61(3):368-77. doi: 10.1016/0041-008x(81)90358-6.
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Toxicity of methoxyacetic acid in rats.甲氧基乙酸对大鼠的毒性
Fundam Appl Toxicol. 1982 Jul-Aug;2(4):158-60. doi: 10.1016/s0272-0590(82)80039-0.
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Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat.乙二醇单甲醚和单乙醚对大鼠的睾丸毒性
覆铜箔层压板工厂中乙二醇单甲醚的血液学和精子毒性作用。
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Correlation between urinary 2-methoxy acetic acid and exposure of 2-methoxy ethanol.尿中2-甲氧基乙酸与2-甲氧基乙醇暴露之间的相关性。
Occup Environ Med. 1999 Oct;56(10):674-8. doi: 10.1136/oem.56.10.674.
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Evaluation of exposure to ethylene glycol monoethyl ether acetates and their possible haematological effects on shipyard painters.评估造船厂油漆工接触乙二醇单乙醚醋酸酯的情况及其可能产生的血液学影响。
Occup Environ Med. 1999 Jun;56(6):378-82. doi: 10.1136/oem.56.6.378.
6
Improved method to measure urinary alkoxyacetic acids.测量尿中烷氧基乙酸的改进方法。
Occup Environ Med. 1999 Jul;56(7):460-7. doi: 10.1136/oem.56.7.460.
7
Urinary alkoxyacetic acids and renal effects of exposure to ethylene glycol ethers.尿中烷氧基乙酸及接触乙二醇醚的肾脏效应。
Occup Environ Med. 1996 Sep;53(9):595-600. doi: 10.1136/oem.53.9.595.
8
Gaschromatographic determination of butoxyacetic acid after hydrolysis of conjugated metabolites in urine from workers exposed to 2-butoxyethanol.气相色谱法测定接触2-丁氧基乙醇的工人尿液中共轭代谢物水解后的丁氧基乙酸含量。
Int Arch Occup Environ Health. 1994;66(4):249-54. doi: 10.1007/BF00454363.
Toxicol Appl Pharmacol. 1983 Jul;69(3):385-99. doi: 10.1016/0041-008x(83)90262-4.
4
Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats.雄性大鼠中乙二醇单甲醚和丙二醇单甲醚的比较代谢与处置
Toxicol Appl Pharmacol. 1983 Feb;67(2):229-37. doi: 10.1016/0041-008x(83)90229-6.
5
Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine.血液和尿液中乙二醇单烷基醚及其推测代谢物的分析。
Environ Health Perspect. 1984 Aug;57:249-53. doi: 10.1289/ehp.8457249.
6
Subchronic inhalation toxicology of ethylene glycol monoethyl ether in the rat and rabbit.乙二醇单乙醚对大鼠和兔子的亚慢性吸入毒理学
Environ Health Perspect. 1984 Aug;57:157-63. doi: 10.1289/ehp.8457157.
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Acute toxicity and recovery in the hemopoietic system of rats after treatment with ethylene glycol monomethyl and monobutyl ethers.用乙二醇单甲醚和单丁醚处理后大鼠造血系统的急性毒性及恢复情况。
Toxicol Appl Pharmacol. 1985 Feb;77(2):187-200. doi: 10.1016/0041-008x(85)90318-7.
8
Gas chromatographic determination of methoxyacetic and ethoxyacetic acid in urine.气相色谱法测定尿液中的甲氧基乙酸和乙氧基乙酸。
Br J Ind Med. 1986 Jan;43(1):62-5. doi: 10.1136/oem.43.1.62.
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Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man.吸入的2-丁氧基乙醇(乙二醇单丁醚)在人体中的毒代动力学。
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Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether.人体实验性暴露于乙二醇单乙醚后乙氧基乙酸的尿排泄情况。
Br J Ind Med. 1986 Sep;43(9):615-9. doi: 10.1136/oem.43.9.615.