Lidegaard O, Soe M, Andersen M V
Stroke. 1986 Jul-Aug;17(4):670-5. doi: 10.1161/01.str.17.4.670.
In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this material we found an average age-adjusted incidence rate of cerebral thromboembolism of 14.4/100.000 among men and 15.5/100.000 among women. The incidence rates rose rapidly with increasing age. Women aged 15-34 had significantly higher incidence rates of brain infarction and TIA compared to those of men of the same age. This was reversed in the age group 35-44. The magnitude of the ratio between the female and the male mean incidence rates by increasing age corresponded exactly to the age distribution of the use of oral contraceptives in Denmark. The relative risk for developing cerebral thromboembolism among users of oral contraceptives was estimated to be 3.2-6.5. The mortality in male patients with brain infarction was 3.3% and in females 1.7%. The mean duration of stay in hospital was 8.8 days for TIA and about 26 days for cerebral infarction. Sixteen percent of men and 13.6% of women had hypertension during their stay.
在1977年至1982年期间，丹麦国家患者登记处记录了15至44岁女性中的1000例脑血栓栓塞发作病例，以及同年龄段男性中的971例病例。脑梗死占病例的70%，短暂性脑缺血发作（TIA）占其余的30%。通过分析这些资料，我们发现男性脑血栓栓塞的年龄调整平均发病率为14.4/100,000，女性为15.5/100,000。发病率随着年龄的增长而迅速上升。15至34岁的女性脑梗死和TIA的发病率明显高于同年龄段男性。在35至44岁年龄组中情况则相反。随着年龄增长，女性与男性平均发病率之比的幅度与丹麦口服避孕药使用的年龄分布完全一致。口服避孕药使用者发生脑血栓栓塞的相对风险估计为3.2至6.5。男性脑梗死患者的死亡率为3.3%，女性为1.7%。TIA患者的平均住院时间为8.8天，脑梗死患者约为26天。16%的男性和13.6%的女性在住院期间患有高血压。
