Pardo-Mindan F J, Guillen F J, Villas C, Vazquez J J
Cancer. 1981 Jun 1;47(11):2611-9. doi: 10.1002/1097-0142(19810601)47:11<2611::aid-cncr2820471116>3.0.co;2-0.
A morphologic and electron microscopic study was made of two chordoid sarcomas. These lesions were compared with two classical chondrosarcomas and two chordomas. These chondrosarcoma cells showed many features common to chondrocytes, such as abundant RER, well-developed Golgi complexes, and microvillous cytoplasmatic membranes. The chordoid sarcomas bore a close morphologic resemblance to the chordomas but the ultrastructural features revealed a close relationship to the chondrosarcomas. The chordoid sarcoma and chondrosarcoma cells had scalloped cytoplasmatic membranes, variable amounts of glycogen, round or oval nuclei and microfibrils, collagen, and electron-dense granules in the ground substance. The chordoma was characterized by the presence of stellate and physalipherous cells, as well as many transitional cells, with varying nuclear morphology; dilated and irregular RER in contact with mitochondria and morphologically varied vacuoles are the main features in the cytoplasm. This study suggests that chordoid sarcoma represents a variety of the chondrosarcoma rather than a form of chordoma. These findings also support the suggestion of Weiss that chordoid sarcoma is an extraskeletal myxoid chondrosarcoma.
对两例脊索样肉瘤进行了形态学和电子显微镜研究。将这些病变与两例经典软骨肉瘤和两例脊索瘤进行了比较。这些软骨肉瘤细胞表现出许多软骨细胞共有的特征，如丰富的粗面内质网、发达的高尔基体复合体和微绒毛状细胞质膜。脊索样肉瘤在形态上与脊索瘤非常相似，但超微结构特征显示与软骨肉瘤关系密切。脊索样肉瘤和软骨肉瘤细胞具有扇贝状细胞质膜、数量不等的糖原、圆形或椭圆形细胞核以及微原纤维、胶原和基质中的电子致密颗粒。脊索瘤的特征是存在星状细胞和泡沫样细胞，以及许多具有不同核形态的过渡细胞；与线粒体接触的扩张且不规则的粗面内质网和形态多样的空泡是细胞质的主要特征。这项研究表明，脊索样肉瘤是软骨肉瘤的一种类型，而不是脊索瘤的一种形式。这些发现也支持了魏斯的观点，即脊索样肉瘤是一种骨外黏液样软骨肉瘤。
