12 个月抗阻训练对糖尿病前期患者腹部脂肪组织和代谢变量变化的影响：一项随机对照试验。
Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial.
机构信息
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Nursing College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
出版信息
J Diabetes Res. 2019 Oct 16;2019:8469739. doi: 10.1155/2019/8469739. eCollection 2019.
OBJECTIVE
To examine the effects of resistance training relative to aerobic training on abdominal adipose tissue and metabolic variables in adults with prediabetes.
METHODS
105 participants with prediabetes were randomized into the resistance training group (RT, = 35), aerobic training group (AT, = 35), and control group (CG, = 35). The participants completed supervised 12-month exercise; the control group followed the primary lifestyle without exercise intervention. The primary outcomes were visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) measured by computed tomography (CT). Secondary outcomes were body composition, lipid profile, and metabolic variables.
RESULTS
A total of 93 participants completed the study. There were nonsignificant differences between groups before intervention. After training, VAT decreased significantly in AT and RT compared with CG ( = 0.001 and = 0.014, respectively). Although no significant difference in SAT was found across groups, SAT decreased significantly over time within each exercise group (all = 0.001). Increase in muscle mass was greater in RT than that in AT and CG ( = 0.031 and = 0.045, respectively). Compared with CG, fasting plasma glucose (FPG) decreased significantly in RT and AT ( = 0.003 and = 0.014, respectively). There was a significant difference in the number of prediabetes who converted to diabetes among AT and RT, as compared with the control group ( = 0.031 and = 0.011, respectively). No significant differences were observed in lipid, waist-to-hip ratio (WHR), body mass index (BMI), fasting insulin (FI), 2-hour postprandial glucose (2hPG), glycosylated hemoglobin (HbA1c), HOMA-IR, and HOMA- across groups.
CONCLUSION
Both aerobic training and resistance training are effective in reducing abdominal adipose tissue and fasting plasma glucose in adults with prediabetes. Importantly, resistance training but not aerobic training is effective in augmenting muscle mass.
TRIAL REGISTRATION
The trial is registered with NCT02561377 (date of registration: 24/09/2015).
目的
研究抗阻训练与有氧训练对糖尿病前期成年人腹部脂肪组织和代谢变量的影响。
方法
将 105 例糖尿病前期患者随机分为抗阻训练组（RT，n=35）、有氧训练组（AT，n=35）和对照组（CG，n=35）。所有参与者均完成了为期 12 个月的监督运动；对照组遵循主要生活方式，不进行运动干预。主要结局指标为 CT 测量的内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。次要结局指标为身体成分、血脂谱和代谢变量。
结果
共有 93 例患者完成了研究。干预前，三组间无显著性差异。训练后，与 CG 相比，AT 和 RT 组的 VAT 显著降低（=0.001 和=0.014）。尽管三组间 SAT 无显著差异，但每个运动组的 SAT 随时间均显著降低（均=0.001）。与 AT 和 CG 相比，RT 组的肌肉质量增加更为显著（=0.031 和=0.045）。与 CG 相比，RT 和 AT 组的空腹血糖（FPG）显著降低（=0.003 和=0.014）。与 CG 相比，AT 和 RT 组中糖尿病前期患者向糖尿病转化的人数差异有统计学意义（=0.031 和=0.011）。三组间血脂、腰臀比（WHR）、体重指数（BMI）、空腹胰岛素（FI）、餐后 2 小时血糖（2hPG）、糖化血红蛋白（HbA1c）、HOMA-IR 和 HOMA-β均无显著差异。
结论
有氧训练和抗阻训练均可有效减少糖尿病前期成年人的腹部脂肪组织和空腹血糖。重要的是，抗阻训练而非有氧训练可有效增加肌肉质量。
试验注册
本试验已在 NCT02561377 注册（注册日期：2015 年 9 月 24 日）。
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