大剂量甲氨蝶呤联合亚叶酸钙解救治疗非小细胞肺癌
High-dose methotrexate with citrovorum factor rescue in non-small-cell lung cancer.
作者信息
Greco F A, Fer M F, Richardson R L, Hande K R, Van Boxtel C J, Oldham R K
出版信息
Cancer Chemother Pharmacol. 1978;1(4):255-7. doi: 10.1007/BF00257159.
PMID:373922
Abstract
Nineteen patients with non-small-cell carcinoma of the lung were treated with high-dose methotrexate and leucovorin rescue. Two partial responses (10.5%) were observed, lasting 13 and 17 weeks. Toxicity was acceptable. It is concluded that the occasional benefit of high-dose methotrexate with leucovorin rescue at this dose and according to the schedule described for these patients does not warrant further study.
摘要
19例非小细胞肺癌患者接受了大剂量甲氨蝶呤及亚叶酸钙解救治疗。观察到2例部分缓解（10.5%），持续时间分别为13周和17周。毒性反应可接受。得出结论，按照所述剂量和方案，对这些患者采用大剂量甲氨蝶呤及亚叶酸钙解救所带来的偶尔益处不值得进一步研究。
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