Kay A B, Gad El Rab M O, Stewart J, Erwa H H
Clin Exp Immunol. 1978 Oct;34(1):106-10.
Hypersensitivity to Chironomidae (non-biting midges) has been a problem in Northern Sudan since about 1927 and is probably due to the working of dams which have produced lake-like conditions on parts of the Blue and main Niles where breeding has evidently increased. Studies were undertaken to determine whether this hypersensitivity is mediated by IgE. Sixteen Sudanese, with bronchial asthma associated with exposure to the chironomid, Cladotanytarsus lewisi ('green nimitti'), were investigated. All patients gave a positive immediate-type skin reaction to an extract of the midge and the majority had markedly elevated concentrations of circulating IgE. Serum from all patients passively sensitized human lung fragments in vitro for the release of histamine and slow-reacting substance of anaphylaxis by the 'nimitti' antigen. This tissue-sensitizing activity could be removed by immunoabsorption with an anti-IgE. These results indicate that this widespread and important hypersensitivity in the Sudan is IgE-mediated and thus may potentially be treated by desensitization.
自1927年左右以来，对摇蚊科（非吸血蠓）的超敏反应在苏丹北部一直是个问题，这可能是由于大坝的修建，在青尼罗河和尼罗河主干道的部分区域形成了类似湖泊的环境，蠓的繁殖明显增加。开展了多项研究以确定这种超敏反应是否由IgE介导。对16名与接触摇蚊Cladotanytarsus lewisi（“绿色尼米蒂”）相关的支气管哮喘苏丹患者进行了调查。所有患者对蠓提取物均产生阳性速发型皮肤反应，且大多数患者循环IgE浓度显著升高。所有患者的血清在体外可被动致敏人肺组织片段，使其通过“尼米蒂”抗原释放组胺和过敏反应慢反应物质。这种组织致敏活性可通过用抗IgE进行免疫吸附去除。这些结果表明，苏丹这种广泛且重要的超敏反应是由IgE介导的，因此可能有望通过脱敏治疗。
