Graduate School of Wuhan Sports University, Wuhan, China.
School of Physical Education, Jinan University, Jinan, China.
J Cell Physiol. 2023 Jul;238(7):1407-1415. doi: 10.1002/jcp.31041. Epub 2023 Jul 2.
Glycosylphosphatidylinositol-specific phospholipase D (GPLD1) is a specific enzyme for glycosylphosphatidylinositol (GPI) anchors, thereby exerting its biological functions by cleaving membrane-associated GPI molecules. GPLD1 is abundant in serum, with a concentration of approximately 5-10 µg/mL. Previous studies have demonstrated that GPLD1 plays a crucial role in the pathogenesis of numerous chronic diseases including disorders of lipid and glucose metabolism, cancer, and neurological disorders. In the present study, we reviewed the structure, functions, and localization of GPLD1 in chronic diseases, as well as exercise-mediated regulation of GPLD1, thus providing a theoretical support to develop GPLD1 as a new therapeutic target for chronic diseases.
糖基磷脂酰肌醇特异性磷脂酶 D（GPLD1）是糖基磷脂酰肌醇（GPI）锚的特异性酶，通过切割膜相关的 GPI 分子来发挥其生物学功能。GPLD1 在血清中含量丰富，浓度约为 5-10μg/mL。先前的研究表明，GPLD1 在包括脂质和葡萄糖代谢紊乱、癌症和神经紊乱在内的许多慢性疾病的发病机制中发挥着关键作用。在本研究中，我们综述了 GPLD1 在慢性疾病中的结构、功能和定位，以及运动介导的 GPLD1 调节，从而为将 GPLD1 开发为慢性疾病的新治疗靶点提供了理论支持。
